Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 503969..504513 Replicon chromosome
Accession NZ_CP039894
Organism Rhizobium pusense strain CFBP5875

Toxin (Protein)


Gene name parE Uniprot ID U4PRC3
Locus tag CFBP5875_RS02505 Protein ID WP_004440407.1
Coordinates 504223..504513 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID U4PRA7
Locus tag CFBP5875_RS02500 Protein ID WP_022555750.1
Coordinates 503969..504220 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5875_RS02470 499067..499756 - 690 WP_003520496.1 HAD family hydrolase -
CFBP5875_RS02475 499971..500651 + 681 WP_137068417.1 GntR family transcriptional regulator -
CFBP5875_RS02480 500692..501153 + 462 WP_072494876.1 DUF1284 domain-containing protein -
CFBP5875_RS02485 501113..502213 - 1101 WP_137068418.1 hypothetical protein -
CFBP5875_RS02495 502450..503595 + 1146 WP_004440405.1 site-specific DNA-methyltransferase -
CFBP5875_RS02500 503969..504220 + 252 WP_022555750.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CFBP5875_RS02505 504223..504513 + 291 WP_004440407.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFBP5875_RS02510 504545..505156 - 612 WP_022555751.1 HAD family phosphatase -
CFBP5875_RS02515 505153..506256 - 1104 WP_112766510.1 A/G-specific adenine glycosylase -
CFBP5875_RS02520 506354..506881 + 528 WP_137068419.1 DUF721 domain-containing protein -
CFBP5875_RS02525 507010..507690 + 681 WP_006309853.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11253.77 Da        Isoelectric Point: 6.6456

>T124510 WP_004440407.1 NZ_CP039894:504223-504513 [Rhizobium pusense]
MGFRLSLPAEEDVIRIAQEGIDLFGPQQARKYHRELFAIFDLISRNPRIARERNELSPSVRIHPFRAHLVVYRVEADDDV
LIVRVRHGHEDWGNEP

Download         Length: 291 bp

>T124510 NZ_CP039894:504223-504513 [Rhizobium pusense]
ATGGGATTTCGCCTTTCTCTGCCTGCGGAAGAAGACGTCATCCGCATAGCGCAAGAAGGCATCGACCTATTTGGACCTCA
GCAAGCGCGAAAGTACCATCGCGAACTTTTCGCAATATTCGACTTGATATCACGGAATCCGAGGATCGCACGCGAGCGTA
ACGAGTTGTCGCCGTCGGTGCGCATTCATCCGTTCAGAGCACATCTGGTGGTCTATCGCGTTGAGGCGGACGACGACGTC
CTCATCGTCCGCGTCCGCCATGGGCACGAGGACTGGGGCAATGAGCCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9316.56 Da        Isoelectric Point: 6.9801

>AT124510 WP_022555750.1 NZ_CP039894:503969-504220 [Rhizobium pusense]
MVTMNISLPGQMKEWVEAQSKTGRYSNASDYVRDLIRKDQERSEKIAAMQGLVDEGLQAPSGHRCEDALFAEAEARSMKR
KIG

Download         Length: 252 bp

>AT124510 NZ_CP039894:503969-504220 [Rhizobium pusense]
ATGGTGACCATGAATATTTCGCTGCCCGGCCAGATGAAGGAATGGGTCGAAGCGCAGTCTAAAACGGGCCGTTACTCCAA
TGCCAGCGACTATGTCCGAGATCTCATCCGAAAGGATCAGGAGCGGAGCGAAAAGATCGCTGCCATGCAGGGTCTGGTGG
ACGAAGGATTGCAGGCTCCCTCCGGTCATCGTTGTGAAGATGCCTTGTTTGCTGAGGCCGAAGCCCGCTCCATGAAACGT
AAAATTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4PRC3

Antitoxin

Source ID Structure
AlphaFold DB A0A098RRB9

References