Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 73257..73788 Replicon plasmid unnamed1
Accession NZ_CP039869
Organism Piscirickettsia salmonis strain Psal-113

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal113_RS16625 Protein ID WP_027243212.1
Coordinates 73501..73788 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal113_RS16620 Protein ID WP_027243211.1
Coordinates 73257..73511 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal113_RS16590 68982..69962 + 981 WP_144420849.1 hypothetical protein -
Psal113_RS16595 70044..70388 - 345 Protein_96 DDE-type integrase/transposase/recombinase -
Psal113_RS16600 70428..71405 - 978 WP_036771347.1 IS5 family transposase -
Psal113_RS16605 71601..71789 + 189 Protein_98 hypothetical protein -
Psal113_RS16610 71886..72863 + 978 WP_036771347.1 IS5 family transposase -
Psal113_RS16615 72878..73039 + 162 WP_155046636.1 hypothetical protein -
Psal113_RS16620 73257..73511 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal113_RS16625 73501..73788 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal113_RS16630 73795..74256 - 462 Protein_103 tail assembly protein -
Psal113_RS16635 74283..75260 - 978 WP_036771347.1 IS5 family transposase -
Psal113_RS16640 75372..76394 + 1023 WP_027243215.1 hypothetical protein -
Psal113_RS16645 76467..76808 + 342 Protein_106 IS6 family transposase -
Psal113_RS16650 76877..77605 - 729 WP_036774350.1 IS6 family transposase -
Psal113_RS16655 77675..78280 + 606 Protein_108 IS982 family transposase -
Psal113_RS16660 78563..78733 + 171 Protein_109 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..164167 164167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T124505 WP_027243212.1 NZ_CP039869:73501-73788 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T124505 NZ_CP039869:73501-73788 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT124505 WP_027243211.1 NZ_CP039869:73257-73511 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT124505 NZ_CP039869:73257-73511 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References