Detailed information of TA system TA124502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2672695..2673458
• Replicon: chromosome
• Accession: NZ_CP039868
• Organism: Piscirickettsia salmonis strain Psal-113

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: A0A1L6TH26
• Locus tag: Psal113_RS13545
• Protein ID: WP_017376502.1
• Coordinates: 2672695..2673204 (-)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A1L6TGZ1
• Locus tag: Psal113_RS13550
• Protein ID: WP_017376501.1
• Coordinates: 2673192..2673458 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Psal113_RS13515	2667707..2668822	+	1116	WP_017376001.1	DSD1 family PLP-dependent enzyme	-
Psal113_RS13520	2668982..2669509	+	528	WP_026063500.1	inorganic diphosphatase	-
Psal113_RS13525	2669509..2670039	+	531	WP_017375999.1	transcriptional repressor	-
Psal113_RS13530	2670370..2670609	+	240	WP_075275277.1	transposase zinc-binding domain-containing protein	-
Psal113_RS18595	2670534..2671196	+	663	WP_174872532.1	transposase	-
Psal113_RS18600	2671200..2671505	+	306	WP_146619445.1	transposase	-
Psal113_RS13540	2671699..2672574	+	876	WP_048875904.1	IS982 family transposase	-
Psal113_RS13545	2672695..2673204	-	510	WP_017376502.1	GNAT family N-acetyltransferase	Toxin
Psal113_RS13550	2673192..2673458	-	267	WP_017376501.1	DUF1778 domain-containing protein	Antitoxin
Psal113_RS13555	2673624..2674598	-	975	WP_048875903.1	IS30 family transposase	-
Psal113_RS13560	2674778..2675398	-	621	WP_075275269.1	transposase	-
Psal113_RS13565	2675395..2675691	-	297	Protein_2680	transposase	-
Psal113_RS13570	2675705..2677108	-	1404	WP_048876031.1	IS4 family transposase	-
Psal113_RS13575	2677232..2677819	-	588	Protein_2682	IS982-like element ISPsa1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2671699..2677819	6120

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (70-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-81)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18875.95 Da
• Isoelectric Point: 8.6859

>T124502 WP_017376502.1 NZ_CP039868:c2673204-2672695 [Piscirickettsia salmonis]
MGEITPPELLESSHDTRGFDCGDIALNEWLQKRGLKNQTSDASRVYVITNRHRVIGYYALASGSVERMIVPGSIARNMPE
TIPVIVLGRLAVDLDYHDQKLGSGLLKDALIRCMLAADTIAAKAVMVHAISDRAKQFYTKNSFVQCPEIEMTLFISIKKI
RQLLKNETK

Nucleotide

• Length: 510 bp

>T124502 NZ_CP039868:c2673204-2672695 [Piscirickettsia salmonis]
TTGGGAGAAATAACACCGCCGGAGCTGCTAGAGTCTAGCCATGATACTCGAGGTTTTGATTGCGGAGATATTGCGCTTAA
TGAGTGGTTACAAAAGCGAGGATTAAAAAATCAGACCTCTGATGCAAGTCGAGTGTATGTAATTACTAATCGTCATCGAG
TGATTGGCTATTATGCGTTAGCCAGTGGCTCTGTGGAGCGAATGATCGTACCTGGCTCCATAGCTCGTAATATGCCAGAG
ACAATTCCGGTGATTGTGCTAGGGCGGCTAGCCGTTGACCTTGATTATCACGATCAAAAACTAGGAAGCGGCTTATTAAA
AGATGCTTTAATTCGGTGTATGCTAGCTGCTGATACAATCGCTGCAAAGGCAGTCATGGTTCATGCAATCTCAGATAGAG
CAAAACAGTTTTATACTAAAAACTCTTTTGTCCAATGTCCTGAAATTGAAATGACTTTATTTATTTCTATAAAAAAAATT
AGGCAACTTCTAAAAAATGAAACAAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10033.51 Da
• Isoelectric Point: 4.4819

>AT124502 WP_017376501.1 NZ_CP039868:c2673458-2673192 [Piscirickettsia salmonis]
MAKVTPISMRTTAEQFDLLTKAANALNIDRTSFILNIACREAENVLLDRRLFQLNDEAFDAFEAALDEPLTQPEKLKRLL
TEPAPWEK

Nucleotide

• Length: 267 bp

>AT124502 NZ_CP039868:c2673458-2673192 [Piscirickettsia salmonis]
ATGGCAAAGGTAACACCGATTAGCATGCGTACAACAGCGGAACAGTTTGATTTACTTACTAAAGCAGCAAATGCATTAAA
TATAGACCGCACATCGTTCATTTTGAATATTGCTTGCCGTGAAGCTGAAAACGTACTGCTAGACCGCCGTTTGTTTCAAT
TAAATGATGAAGCTTTTGATGCCTTTGAGGCAGCACTAGATGAGCCATTAACTCAACCAGAGAAATTAAAACGCTTACTA
ACGGAGCCTGCACCTTGGGAGAAATAA

Structures

Toxin

• AlphaFold DB: A0A1L6TH26

Antitoxin

• AlphaFold DB: A0A1L6TGZ1