Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 18806..19407 | Replicon | plasmid PNCS014880 strain 14[5]12:i:- |
| Accession | NZ_CP039862 | ||
| Organism | Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014880 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | U9YA20 |
| Locus tag | E5O17_RS26310 | Protein ID | WP_001216045.1 |
| Coordinates | 18806..19186 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | E5O17_RS26315 | Protein ID | WP_001190712.1 |
| Coordinates | 19186..19407 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E5O17_RS26285 | 14247..15731 | - | 1485 | WP_000124150.1 | terminase | - |
| E5O17_RS26290 | 15731..16924 | - | 1194 | WP_000219625.1 | hypothetical protein | - |
| E5O17_RS26295 | 17010..17462 | - | 453 | WP_001326849.1 | late promoter-activating protein | - |
| E5O17_RS26300 | 17551..18594 | - | 1044 | WP_023356283.1 | DUF968 domain-containing protein | - |
| E5O17_RS26305 | 18622..18801 | - | 180 | WP_001339207.1 | hypothetical protein | - |
| E5O17_RS26310 | 18806..19186 | - | 381 | WP_001216045.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| E5O17_RS26315 | 19186..19407 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| E5O17_RS26320 | 19480..19869 | - | 390 | WP_000506730.1 | DNA repair protein | - |
| E5O17_RS26325 | 20044..20628 | + | 585 | WP_023356284.1 | hypothetical protein | - |
| E5O17_RS26330 | 20629..20991 | + | 363 | WP_042102765.1 | hypothetical protein | - |
| E5O17_RS26335 | 21003..21242 | - | 240 | WP_023356286.1 | DNA polymerase III subunit theta | - |
| E5O17_RS26340 | 21245..21445 | - | 201 | WP_032145427.1 | hypothetical protein | - |
| E5O17_RS26345 | 21557..22315 | - | 759 | WP_032353390.1 | hypothetical protein | - |
| E5O17_RS26350 | 22312..22686 | - | 375 | WP_032353387.1 | hypothetical protein | - |
| E5O17_RS26355 | 22693..22986 | - | 294 | WP_000269001.1 | hypothetical protein | - |
| E5O17_RS26360 | 23165..23398 | - | 234 | WP_000517421.1 | hypothetical protein | - |
| E5O17_RS26365 | 23481..24176 | - | 696 | WP_052896298.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..91904 | 91904 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 18709.44 Da Isoelectric Point: 5.5500
>T124501 WP_001216045.1 NZ_CP039862:c19186-18806 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 381 bp
>T124501 NZ_CP039862:c19186-18806 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin
Download Length: 74 a.a. Molecular weight: 10909.08 Da Isoelectric Point: 5.5500
>AT124501 WP_001190712.1 NZ_CP039862:c19407-19186 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 222 bp
>AT124501 NZ_CP039862:c19407-19186 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CLP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |