Detailed information of TA system TA124492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3117028..3117715
• Replicon: chromosome
• Accession: NZ_CP039851
• Organism: Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7U4FBY8
• Locus tag: FCU27_RS15415
• Protein ID: WP_011799298.1
• Coordinates: 3117272..3117715 (+)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TFH0
• Locus tag: FCU27_RS15410
• Protein ID: WP_003414620.1
• Coordinates: 3117028..3117285 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCU27_RS15390	3112348..3113202	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
FCU27_RS15395	3113258..3114421	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
FCU27_RS15400	3114438..3115652	-	1215	WP_011799297.1	zinc metalloprotease Rip	-
FCU27_RS15405	3115660..3116901	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-
FCU27_RS15410	3117028..3117285	+	258	WP_003414620.1	ribbon-helix-helix domain-containing protein	Antitoxin
FCU27_RS15415	3117272..3117715	+	444	WP_011799298.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCU27_RS15420	3117795..3118457	+	663	WP_003414630.1	cell surface glycolipoprotein Mpt83	-
FCU27_RS15425	3118553..3118744	+	192	WP_003414632.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FCU27_RS15430	3119076..3120824	+	1749	WP_003912869.1	cytochrome c biogenesis protein DipZ	-
FCU27_RS15435	3120920..3121501	+	582	WP_003414644.1	fasciclin domain-containing protein	-
FCU27_RS15440	3121601..3121867	+	267	WP_031657293.1	DUF2631 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 16625.74 Da
• Isoelectric Point: 6.4890

>T124492 WP_011799298.1 NZ_CP039851:3117272-3117715 [Mycobacterium tuberculosis variant bovis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDTLLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Nucleotide

• Length: 444 bp

>T124492 NZ_CP039851:3117272-3117715 [Mycobacterium tuberculosis variant bovis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACACCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9013.22 Da
• Isoelectric Point: 10.8344

>AT124492 WP_003414620.1 NZ_CP039851:3117028-3117285 [Mycobacterium tuberculosis variant bovis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Nucleotide

• Length: 258 bp

>AT124492 NZ_CP039851:3117028-3117285 [Mycobacterium tuberculosis variant bovis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBY8

Antitoxin

• AlphaFold DB: G0TFH0