124485

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2874633..2875347 Replicon chromosome
Accession NZ_CP039851
Organism Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FCU27_RS14025 Protein ID WP_003413460.1
Coordinates 2874907..2875347 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FCU27_RS14020 Protein ID WP_003413456.1
Coordinates 2874633..2874920 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU27_RS13985 2870065..2870310 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FCU27_RS13990 2870307..2870711 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FCU27_RS13995 2870928..2871548 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FCU27_RS14000 2871559..2872053 + 495 WP_003413444.1 DUF2617 family protein -
FCU27_RS14005 2872050..2872481 + 432 WP_003413445.1 DUF4247 domain-containing protein -
FCU27_RS14010 2872506..2872954 + 449 Protein_2615 DUF350 domain-containing protein -
FCU27_RS14015 2872951..2874522 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FCU27_RS14020 2874633..2874920 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FCU27_RS14025 2874907..2875347 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FCU27_RS14030 2875368..2876123 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FCU27_RS14035 2876256..2876852 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FCU27_RS14040 2876860..2877704 - 845 Protein_2621 acyl-CoA thioesterase II -
FCU27_RS14045 2877733..2878632 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FCU27_RS14050 2878760..2879434 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T124485 WP_003413460.1 NZ_CP039851:2874907-2875347 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T124485 NZ_CP039851:2874907-2875347 [Mycobacterium tuberculosis variant bovis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT124485 WP_003413456.1 NZ_CP039851:2874633-2874920 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT124485 NZ_CP039851:2874633-2874920 [Mycobacterium tuberculosis variant bovis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References