Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2814297..2814934 Replicon chromosome
Accession NZ_CP039851
Organism Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag FCU27_RS13735 Protein ID WP_003413180.1
Coordinates 2814297..2814692 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag FCU27_RS13740 Protein ID WP_003413183.1
Coordinates 2814689..2814934 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU27_RS13695 2810382..2811041 + 660 WP_003900846.1 LppA family lipoprotein -
FCU27_RS13700 2811038..2811697 + 660 WP_003900847.1 hypothetical protein -
FCU27_RS13705 2811694..2812356 + 663 WP_003900848.1 hypothetical protein -
FCU27_RS13710 2812353..2812631 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FCU27_RS13715 2812724..2813137 + 414 WP_003413164.1 PIN domain nuclease -
FCU27_RS13720 2813176..2813433 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
FCU27_RS13725 2813430..2813807 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FCU27_RS13730 2813823..2814197 - 375 WP_003413177.1 hypothetical protein -
FCU27_RS13735 2814297..2814692 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
FCU27_RS13740 2814689..2814934 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
FCU27_RS13750 2815345..2815764 - 420 WP_003413190.1 A24 family peptidase -
FCU27_RS13755 2815776..2816603 - 828 WP_010950736.1 shikimate dehydrogenase -
FCU27_RS13760 2816581..2817834 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FCU27_RS13765 2817827..2818339 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T124484 WP_003413180.1 NZ_CP039851:c2814692-2814297 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T124484 NZ_CP039851:c2814692-2814297 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT124484 WP_003413183.1 NZ_CP039851:c2814934-2814689 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT124484 NZ_CP039851:c2814934-2814689 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References