124479

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2362437..2362966 Replicon chromosome
Accession NZ_CP039851
Organism Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FCU27_RS11485 Protein ID WP_003411124.1
Coordinates 2362437..2362754 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FCU27_RS11490 Protein ID WP_003411127.1
Coordinates 2362751..2362966 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU27_RS11455 2357574..2358650 + 1077 WP_003411110.1 hypothetical protein -
FCU27_RS11460 2358647..2358928 + 282 WP_019283661.1 hypothetical protein -
FCU27_RS11465 2358964..2360037 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
FCU27_RS11470 2360042..2360572 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FCU27_RS11475 2360620..2361966 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FCU27_RS11485 2362437..2362754 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCU27_RS11490 2362751..2362966 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FCU27_RS11495 2363221..2364279 + 1059 WP_003411129.1 hypothetical protein -
FCU27_RS11500 2364409..2364765 - 357 WP_003411130.1 hypothetical protein -
FCU27_RS11505 2364860..2365642 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FCU27_RS11510 2365910..2366200 - 291 WP_003900476.1 YggT family protein -
FCU27_RS11515 2366362..2367018 - 657 WP_003411133.1 cell division protein SepF -
FCU27_RS11520 2367084..2367860 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T124479 WP_003411124.1 NZ_CP039851:c2362754-2362437 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T124479 NZ_CP039851:c2362754-2362437 [Mycobacterium tuberculosis variant bovis]
ATGACGCGTAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT124479 WP_003411127.1 NZ_CP039851:c2362966-2362751 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT124479 NZ_CP039851:c2362966-2362751 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References