Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2186093..2186637 Replicon chromosome
Accession NZ_CP039851
Organism Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FCU27_RS10610 Protein ID WP_003409896.1
Coordinates 2186093..2186389 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FCU27_RS10615 Protein ID WP_003409899.1
Coordinates 2186386..2186637 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU27_RS10555 2181126..2181476 - 351 WP_003409871.1 hypothetical protein -
FCU27_RS10560 2181487..2182389 - 903 WP_003409874.1 hypothetical protein -
FCU27_RS10565 2182410..2182601 - 192 WP_003409876.1 hypothetical protein -
FCU27_RS10570 2182602..2182898 - 297 WP_003409877.1 hypothetical protein -
FCU27_RS10575 2183138..2183353 + 216 WP_003409878.1 antitoxin -
FCU27_RS10580 2183350..2183661 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FCU27_RS21325 2183635..2184156 - 522 WP_010950637.1 hypothetical protein -
FCU27_RS10590 2184131..2184508 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FCU27_RS10595 2184550..2184999 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FCU27_RS10600 2184996..2185541 + 546 WP_003409891.1 SecB-like chaperone -
FCU27_RS10605 2185430..2186044 - 615 WP_003901296.1 hypothetical protein -
FCU27_RS10610 2186093..2186389 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCU27_RS10615 2186386..2186637 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FCU27_RS10620 2186624..2187118 + 495 WP_003899099.1 hypothetical protein -
FCU27_RS10625 2187278..2187685 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FCU27_RS10630 2187689..2187961 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FCU27_RS10635 2187994..2189214 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FCU27_RS10650 2190101..2190517 + 417 WP_162014414.1 hypothetical protein -
FCU27_RS10655 2190602..2191126 + 525 WP_011799234.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T124472 WP_003409896.1 NZ_CP039851:c2186389-2186093 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T124472 NZ_CP039851:c2186389-2186093 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT124472 WP_003409899.1 NZ_CP039851:c2186637-2186386 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT124472 NZ_CP039851:c2186637-2186386 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References