Detailed information of TA system TA124462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385995..1386683
• Replicon: chromosome
• Accession: NZ_CP039851
• Organism: Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FCU27_RS06880
• Protein ID: WP_003406304.1
• Coordinates: 1386252..1386683 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FCU27_RS06875
• Protein ID: WP_003406302.1
• Coordinates: 1385995..1386255 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCU27_RS06855	1381572..1382396	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FCU27_RS06860	1382401..1383582	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FCU27_RS06865	1383659..1384759	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FCU27_RS06870	1384930..1385919	+	990	WP_003406301.1	malate dehydrogenase	-
FCU27_RS06875	1385995..1386255	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FCU27_RS06880	1386252..1386683	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCU27_RS06885	1386706..1388394	-	1689	WP_003910308.1	PE family protein	-
FCU27_RS06895	1388574..1389434	+	861	WP_003406306.1	hypothetical protein	-
FCU27_RS06900	1389515..1390345	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FCU27_RS06905	1390402..1390695	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FCU27_RS06910	1390692..1390961	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T124462 WP_003406304.1 NZ_CP039851:1386252-1386683 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T124462 NZ_CP039851:1386252-1386683 [Mycobacterium tuberculosis variant bovis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT124462 WP_003406302.1 NZ_CP039851:1385995-1386255 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT124462 NZ_CP039851:1385995-1386255 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6