124460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1232522..1233153 Replicon chromosome
Accession NZ_CP039851
Organism Mycobacterium tuberculosis variant bovis strain Danish delta-sapM

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FCU27_RS06130 Protein ID WP_003405820.1
Coordinates 1232522..1232833 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FCU27_RS06135 Protein ID WP_003405836.1
Coordinates 1232833..1233153 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU27_RS06110 1228004..1229428 - 1425 WP_003405805.1 class II fumarate hydratase -
FCU27_RS06115 1229459..1230547 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
FCU27_RS06120 1230603..1231247 + 645 WP_174813088.1 DUF4245 domain-containing protein -
FCU27_RS06125 1231254..1232410 - 1157 Protein_1139 AI-2E family transporter -
FCU27_RS06130 1232522..1232833 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FCU27_RS06135 1232833..1233153 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FCU27_RS06140 1233163..1234688 + 1526 Protein_1142 carboxylesterase/lipase family protein -
FCU27_RS06145 1234706..1235818 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FCU27_RS06150 1235828..1236085 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FCU27_RS06155 1236075..1237322 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FCU27_RS06160 1237319..1237957 - 639 WP_011799158.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T124460 WP_003405820.1 NZ_CP039851:c1232833-1232522 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T124460 NZ_CP039851:c1232833-1232522 [Mycobacterium tuberculosis variant bovis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT124460 WP_003405836.1 NZ_CP039851:c1233153-1232833 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT124460 NZ_CP039851:c1233153-1232833 [Mycobacterium tuberculosis variant bovis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References