Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3780573..3781102 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FCU26_RS18525 Protein ID WP_003417760.1
Coordinates 3780845..3781102 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FCU26_RS18520 Protein ID WP_003417757.1
Coordinates 3780573..3780848 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU26_RS18480 3775604..3776902 - 1299 WP_011799343.1 PPE family protein -
FCU26_RS21815 3777371..3778808 - 1438 Protein_3457 FAD-binding oxidoreductase -
FCU26_RS18505 3778911..3779300 + 390 WP_010950876.1 DUF732 domain-containing protein -
FCU26_RS18510 3779314..3779607 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FCU26_RS18515 3779604..3780449 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FCU26_RS18520 3780573..3780848 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FCU26_RS18525 3780845..3781102 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FCU26_RS18530 3781144..3782334 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FCU26_RS18535 3782451..3782819 + 369 WP_003417765.1 FHA domain-containing protein -
FCU26_RS18540 3782816..3783367 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FCU26_RS18545 3783374..3783955 - 582 WP_003417769.1 ATP/GTP-binding protein -
FCU26_RS18550 3783936..3784304 - 369 WP_003417772.1 DUF742 domain-containing protein -
FCU26_RS18555 3784282..3784674 - 393 WP_011799344.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T124436 WP_003417760.1 NZ_CP039850:3780845-3781102 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T124436 NZ_CP039850:3780845-3781102 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT124436 WP_003417757.1 NZ_CP039850:3780573-3780848 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT124436 NZ_CP039850:3780573-3780848 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References