Detailed information of TA system TA124434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3639867..3640541
• Replicon: chromosome
• Accession: NZ_CP039850
• Organism: Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FCU26_RS17890
• Protein ID: WP_003417282.1
• Coordinates: 3639867..3640295 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FCU26_RS17895
• Protein ID: WP_003417286.1
• Coordinates: 3640299..3640541 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCU26_RS17865	3635689..3636090	-	402	WP_003417264.1	cytidine deaminase	-
FCU26_RS17870	3636231..3636665	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FCU26_RS17875	3636662..3637096	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FCU26_RS17880	3637225..3638997	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FCU26_RS17885	3638997..3639788	+	792	WP_010950870.1	succinate dehydrogenase iron-sulfur subunit	-
FCU26_RS17890	3639867..3640295	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCU26_RS17895	3640299..3640541	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FCU26_RS17900	3640663..3641277	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FCU26_RS17905	3641323..3642231	+	909	Protein_3349	AarF/ABC1/UbiB kinase family protein	-
FCU26_RS17910	3642265..3642543	-	279	WP_003899963.1	transcriptional regulator WhiB7	-
FCU26_RS17915	3642973..3645075	-	2103	WP_003416822.1	ATP-dependent DNA helicase UvrD2	-
FCU26_RS17920	3645199..3645453	+	255	WP_003416827.1	mycoredoxin Mrx1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T124434 WP_003417282.1 NZ_CP039850:c3640295-3639867 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T124434 NZ_CP039850:c3640295-3639867 [Mycobacterium tuberculosis variant bovis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT124434 WP_003417286.1 NZ_CP039850:c3640541-3640299 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT124434 NZ_CP039850:c3640541-3640299 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59