Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3070553..3071157 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FCU26_RS15180 Protein ID WP_003414492.1
Coordinates 3070553..3070945 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag FCU26_RS15185 Protein ID WP_003414495.1
Coordinates 3070942..3071157 (-) Length 72 a.a.

Genomic Context

FCU26_RS15190FCU26_RS15150FCU26_RS15155FCU26_RS15160FCU26_RS15165FCU26_RS15170FCU26_RS15175FCU26_RS15180FCU26_RS15185FCU26_RS15195FCU26_RS15200FCU26_RS15205FCU26_RS15210
Location: 3071204..3071953 (750 bp)
Type: Others
Protein ID: WP_003414497.1
Location: 3065703..3066491 (789 bp)
Type: Others
Protein ID: WP_003917092.1
Location: 3066825..3067370 (546 bp)
Type: Others
Protein ID: WP_003904931.1
Location: 3067642..3068526 (885 bp)
Type: Others
Protein ID: WP_003414409.1
Location: 3068529..3069416 (888 bp)
Type: Others
Protein ID: WP_003414414.1
Location: 3069721..3070266 (546 bp)
Type: Others
Protein ID: WP_003899500.1
Location: 3070263..3070532 (270 bp)
Type: Others
Protein ID: WP_003414489.1
Location: 3070553..3070945 (393 bp)
Type: Toxin
Protein ID: WP_003414492.1
Location: 3070942..3071157 (216 bp)
Type: Antitoxin
Protein ID: WP_003414495.1
Location: 3072032..3073114 (1083 bp)
Type: Others
Protein ID: WP_011799293.1
Location: 3073107..3074417 (1311 bp)
Type: Others
Protein ID: Protein_2841
Location: 3074420..3075247 (828 bp)
Type: Others
Protein ID: WP_003414504.1
Location: 3075244..3076155 (912 bp)
Type: Others
Protein ID: WP_003414505.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS151503065703..3066491-789WP_003917092.1CRISPR-associated endoribonuclease Cas6-
FCU26_RS151553066825..3067370-546WP_003904931.1DUF1802 family protein-
FCU26_RS151603067642..3068526-885WP_003414409.1nucleotidyl transferase AbiEii/AbiGii toxin family protein-
FCU26_RS151653068529..3069416-888WP_003414414.1type IV toxin-antitoxin system AbiEi family antitoxin-
FCU26_RS151703069721..3070266-546WP_003899500.1DUF1802 family protein-
FCU26_RS151753070263..3070532-270WP_003414489.1DUF2277 family protein-
FCU26_RS151803070553..3070945-393WP_003414492.1type II toxin-antitoxin system VapC family toxinToxin
FCU26_RS151853070942..3071157-216WP_003414495.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FCU26_RS151903071204..3071953+750WP_003414497.1enoyl-CoA hydratase-
FCU26_RS151953072032..3073114-1083WP_011799293.1ABC transporter ATP-binding protein-
FCU26_RS152003073107..3074417-1311Protein_2841ABC transporter substrate-binding protein-
FCU26_RS152053074420..3075247-828WP_003414504.1carbohydrate ABC transporter permease-
FCU26_RS152103075244..3076155-912WP_003414505.1sugar ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T124430 WP_003414492.1 NZ_CP039850:c3070945-3070553 [Mycobacterium tuberculosis variant bovis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T124430 NZ_CP039850:c3070945-3070553 [Mycobacterium tuberculosis variant bovis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT124430 WP_003414495.1 NZ_CP039850:c3071157-3070942 [Mycobacterium tuberculosis variant bovis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT124430 NZ_CP039850:c3071157-3070942 [Mycobacterium tuberculosis variant bovis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4BWM8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829CBY8

References