Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3043562..3044132 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FCU26_RS15035 Protein ID WP_003414166.1
Coordinates 3043562..3043918 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FCU26_RS15040 Protein ID WP_003901465.1
Coordinates 3043902..3044132 (-) Length 77 a.a.

Genomic Context

FCU26_RS15025FCU26_RS15030FCU26_RS15050FCU26_RS15060FCU26_RS15065FCU26_RS15070FCU26_RS15075FCU26_RS15080FCU26_RS15015FCU26_RS15020FCU26_RS15035FCU26_RS15040FCU26_RS15045FCU26_RS21780
Location: 3041205..3041792 (588 bp)
Type: Others
Protein ID: WP_003914429.1
Location: 3041811..3043460 (1650 bp)
Type: Others
Protein ID: WP_003899485.1
Location: 3045409..3045684 (276 bp)
Type: Others
Protein ID: WP_003911993.1
Location: 3046262..3046666 (405 bp)
Type: Others
Protein ID: WP_003414181.1
Location: 3046663..3046854 (192 bp)
Type: Others
Protein ID: WP_003414184.1
Location: 3046918..3048207 (1290 bp)
Type: Others
Protein ID: Protein_2815
Location: 3048441..3048698 (258 bp)
Type: Others
Protein ID: WP_003899489.1
Location: 3048803..3049114 (312 bp)
Type: Others
Protein ID: WP_010950777.1
Location: 3039014..3040702 (1689 bp)
Type: Others
Protein ID: WP_003414155.1
Location: 3040706..3041032 (327 bp)
Type: Others
Protein ID: WP_003414157.1
Location: 3043562..3043918 (357 bp)
Type: Toxin
Protein ID: WP_003414166.1
Location: 3043902..3044132 (231 bp)
Type: Antitoxin
Protein ID: WP_003901465.1
Location: 3044175..3045218 (1044 bp)
Type: Others
Protein ID: WP_003414172.1
Location: 3045860..3046114 (255 bp)
Type: Others
Protein ID: WP_003917684.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS150153039014..3040702-1689WP_003414155.1alpha/beta hydrolase family protein-
FCU26_RS150203040706..3041032-327WP_003414157.1hypothetical protein-
FCU26_RS150253041205..3041792+588WP_003914429.1DUF3558 family protein-
FCU26_RS150303041811..3043460+1650WP_003899485.1CocE/NonD family hydrolase-
FCU26_RS150353043562..3043918-357WP_003414166.1type II toxin-antitoxin system toxin endoribonuclease MazF9Toxin
FCU26_RS150403043902..3044132-231WP_003901465.1antitoxin MazEAntitoxin
FCU26_RS150453044175..3045218-1044WP_003414172.1DUF2293 domain-containing protein-
FCU26_RS150503045409..3045684+276WP_003911993.1DUF1778 domain-containing protein-
FCU26_RS217803045860..3046114-255WP_003917684.1hypothetical protein-
FCU26_RS150603046262..3046666+405WP_003414181.1hypothetical protein-
FCU26_RS150653046663..3046854+192WP_003414184.1hypothetical protein-
FCU26_RS150703046918..3048207+1290Protein_2815transposase family protein-
FCU26_RS150753048441..3048698+258WP_003899489.1hypothetical protein-
FCU26_RS150803048803..3049114+312WP_010950777.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T124428 WP_003414166.1 NZ_CP039850:c3043918-3043562 [Mycobacterium tuberculosis variant bovis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T124428 NZ_CP039850:c3043918-3043562 [Mycobacterium tuberculosis variant bovis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT124428 WP_003901465.1 NZ_CP039850:c3044132-3043902 [Mycobacterium tuberculosis variant bovis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT124428 NZ_CP039850:c3044132-3043902 [Mycobacterium tuberculosis variant bovis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6L2A
PDB5HJZ
PDB6KYT
PDB6L29
PDB7DU5
PDB6KYS

Antitoxin

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Source
ID
Structure
PDB7DU5
PDB6KYT
AlphaFold DBA0A7U4FBW3

References