Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3003566..3004245 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag FCU26_RS14805 Protein ID WP_003414059.1
Coordinates 3003566..3003982 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag FCU26_RS14810 Protein ID WP_003414061.1
Coordinates 3003979..3004245 (-) Length 89 a.a.

Genomic Context

FCU26_RS14850FCU26_RS14785FCU26_RS14790FCU26_RS14795FCU26_RS14800FCU26_RS14805FCU26_RS14810FCU26_RS14815FCU26_RS14820FCU26_RS14825FCU26_RS14830FCU26_RS14840FCU26_RS14845
Location: 3008032..3008769 (738 bp)
Type: Others
Protein ID: WP_011799288.1
Location: 2999618..3000520 (903 bp)
Type: Others
Protein ID: WP_003900564.1
Location: 3000589..3001341 (753 bp)
Type: Others
Protein ID: WP_003899465.1
Location: 3001585..3001860 (276 bp)
Type: Others
Protein ID: WP_003414055.1
Location: 3001857..3003479 (1623 bp)
Type: Others
Protein ID: WP_003414057.1
Location: 3003566..3003982 (417 bp)
Type: Toxin
Protein ID: WP_003414059.1
Location: 3003979..3004245 (267 bp)
Type: Antitoxin
Protein ID: WP_003414061.1
Location: 3004271..3004666 (396 bp)
Type: Others
Protein ID: WP_003414064.1
Location: 3004663..3004932 (270 bp)
Type: Others
Protein ID: WP_003414066.1
Location: 3004942..3006036 (1095 bp)
Type: Others
Protein ID: WP_003414068.1
Location: 3006033..3006452 (420 bp)
Type: Others
Protein ID: Protein_2768
Location: 3006526..3007005 (480 bp)
Type: Others
Protein ID: WP_003414073.1
Location: 3007076..3007876 (801 bp)
Type: Others
Protein ID: WP_003911953.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS147852999618..3000520-903WP_003900564.14-hydroxy-tetrahydrodipicolinate synthase-
FCU26_RS147903000589..3001341-753WP_003899465.1FAD-dependent thymidylate synthase-
FCU26_RS147953001585..3001860-276WP_003414055.1type I restriction endonuclease subunit S-
FCU26_RS148003001857..3003479-1623WP_003414057.1type I restriction-modification system subunit M-
FCU26_RS148053003566..3003982-417WP_003414059.1type II toxin-antitoxin system toxin ribonuclease C21Toxin
FCU26_RS148103003979..3004245-267WP_003414061.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
FCU26_RS148153004271..3004666-396WP_003414064.1type II toxin-antitoxin system VapC family toxin-
FCU26_RS148203004663..3004932-270WP_003414066.1type II toxin-antitoxin system VapB family antitoxin-
FCU26_RS148253004942..3006036-1095WP_003414068.1restriction endonuclease subunit S-
FCU26_RS148303006033..3006452-420Protein_2768winged helix-turn-helix domain-containing protein-
FCU26_RS148403006526..3007005-480WP_003414073.1dihydrofolate reductase-
FCU26_RS148453007076..3007876-801WP_003911953.1thymidylate synthase-
FCU26_RS148503008032..3008769+738WP_011799288.1dienelactone hydrolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T124426 WP_003414059.1 NZ_CP039850:c3003982-3003566 [Mycobacterium tuberculosis variant bovis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

>T124426 NZ_CP039850:c3003982-3003566 [Mycobacterium tuberculosis variant bovis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT124426 WP_003414061.1 NZ_CP039850:c3004245-3003979 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT124426 NZ_CP039850:c3004245-3003979 [Mycobacterium tuberculosis variant bovis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5SV2

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TF64

References