Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2814281..2814918 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag FCU26_RS13735 Protein ID WP_003413180.1
Coordinates 2814281..2814676 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag FCU26_RS13740 Protein ID WP_003413183.1
Coordinates 2814673..2814918 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU26_RS13695 2810366..2811025 + 660 WP_003900846.1 LppA family lipoprotein -
FCU26_RS13700 2811022..2811681 + 660 WP_003900847.1 hypothetical protein -
FCU26_RS13705 2811678..2812340 + 663 WP_003900848.1 hypothetical protein -
FCU26_RS13710 2812337..2812615 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FCU26_RS13715 2812708..2813121 + 414 WP_003413164.1 PIN domain nuclease -
FCU26_RS13720 2813160..2813417 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
FCU26_RS13725 2813414..2813791 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FCU26_RS13730 2813807..2814181 - 375 WP_003413177.1 hypothetical protein -
FCU26_RS13735 2814281..2814676 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
FCU26_RS13740 2814673..2814918 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
FCU26_RS13750 2815329..2815748 - 420 WP_003413190.1 A24 family peptidase -
FCU26_RS13755 2815760..2816587 - 828 WP_010950736.1 shikimate dehydrogenase -
FCU26_RS13760 2816565..2817818 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FCU26_RS13765 2817811..2818323 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T124424 WP_003413180.1 NZ_CP039850:c2814676-2814281 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T124424 NZ_CP039850:c2814676-2814281 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT124424 WP_003413183.1 NZ_CP039850:c2814918-2814673 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT124424 NZ_CP039850:c2814918-2814673 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References