Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2812708..2813417 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag FCU26_RS13715 Protein ID WP_003413164.1
Coordinates 2812708..2813121 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag FCU26_RS13720 Protein ID WP_003413167.1
Coordinates 2813160..2813417 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU26_RS13680 2808418..2808732 + 315 WP_009937839.1 hypothetical protein -
FCU26_RS13685 2809028..2810239 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FCU26_RS13695 2810366..2811025 + 660 WP_003900846.1 LppA family lipoprotein -
FCU26_RS13700 2811022..2811681 + 660 WP_003900847.1 hypothetical protein -
FCU26_RS13705 2811678..2812340 + 663 WP_003900848.1 hypothetical protein -
FCU26_RS13710 2812337..2812615 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FCU26_RS13715 2812708..2813121 + 414 WP_003413164.1 PIN domain nuclease Toxin
FCU26_RS13720 2813160..2813417 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
FCU26_RS13725 2813414..2813791 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FCU26_RS13730 2813807..2814181 - 375 WP_003413177.1 hypothetical protein -
FCU26_RS13735 2814281..2814676 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
FCU26_RS13740 2814673..2814918 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
FCU26_RS13750 2815329..2815748 - 420 WP_003413190.1 A24 family peptidase -
FCU26_RS13755 2815760..2816587 - 828 WP_010950736.1 shikimate dehydrogenase -
FCU26_RS13760 2816565..2817818 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FCU26_RS13765 2817811..2818323 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T124422 WP_003413164.1 NZ_CP039850:2812708-2813121 [Mycobacterium tuberculosis variant bovis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T124422 NZ_CP039850:2812708-2813121 [Mycobacterium tuberculosis variant bovis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT124422 WP_003413167.1 NZ_CP039850:2813160-2813417 [Mycobacterium tuberculosis variant bovis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT124422 NZ_CP039850:2813160-2813417 [Mycobacterium tuberculosis variant bovis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References