Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2325524..2326219 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FCU26_RS11275 Protein ID WP_003410811.1
Coordinates 2325524..2325958 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FCU26_RS11280 Protein ID WP_003410814.1
Coordinates 2325965..2326219 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCU26_RS11265 2321678..2324719 + 3042 WP_010950658.1 DEAD/DEAH box helicase -
FCU26_RS11270 2324712..2325545 + 834 WP_003899172.1 SWIM zinc finger family protein -
FCU26_RS11275 2325524..2325958 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FCU26_RS11280 2325965..2326219 - 255 WP_003410814.1 antitoxin Antitoxin
FCU26_RS11285 2326235..2326492 - 258 WP_003410816.1 hypothetical protein -
FCU26_RS11295 2327439..2327735 + 297 WP_003410820.1 PE family protein -
FCU26_RS11300 2327791..2328522 + 732 WP_003900467.1 PPE family protein -
FCU26_RS11305 2329062..2329808 - 747 WP_003901330.1 proteasome subunit alpha -
FCU26_RS11310 2329805..2330680 - 876 WP_003411023.1 proteasome subunit beta -
FCU26_RS11315 2330677..2330871 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T124418 WP_003410811.1 NZ_CP039850:c2325958-2325524 [Mycobacterium tuberculosis variant bovis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T124418 NZ_CP039850:c2325958-2325524 [Mycobacterium tuberculosis variant bovis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT124418 WP_003410814.1 NZ_CP039850:c2326219-2325965 [Mycobacterium tuberculosis variant bovis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT124418 NZ_CP039850:c2326219-2325965 [Mycobacterium tuberculosis variant bovis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References