Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1751105..1751718 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag FCU26_RS08555 Protein ID WP_003407786.1
Coordinates 1751314..1751718 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag FCU26_RS08550 Protein ID WP_009935474.1
Coordinates 1751105..1751308 (+) Length 68 a.a.

Genomic Context

FCU26_RS08535FCU26_RS08540FCU26_RS08545FCU26_RS08550FCU26_RS08555FCU26_RS08560FCU26_RS08565
Location: 1746369..1749272 (2904 bp)
Type: Others
Protein ID: WP_003407779.1
Location: 1749282..1749728 (447 bp)
Type: Others
Protein ID: WP_003407780.1
Location: 1749763..1751052 (1290 bp)
Type: Others
Protein ID: WP_003407781.1
Location: 1751105..1751308 (204 bp)
Type: Antitoxin
Protein ID: WP_009935474.1
Location: 1751314..1751718 (405 bp)
Type: Toxin
Protein ID: WP_003407786.1
Location: 1751735..1753476 (1742 bp)
Type: Others
Protein ID: Protein_1595
Location: 1753469..1755766 (2298 bp)
Type: Others
Protein ID: WP_003407790.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS085351746369..1749272+2904WP_003407779.1MMPL family transporter-
FCU26_RS085401749282..1749728+447WP_003407780.1F420H(2)-dependent quinone reductase-
FCU26_RS085451749763..1751052+1290WP_003407781.1threonine ammonia-lyase-
FCU26_RS085501751105..1751308+204WP_009935474.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
FCU26_RS085551751314..1751718+405WP_003407786.1type II toxin-antitoxin system toxin ribonuclease VapC11Toxin
FCU26_RS085601751735..1753476-1742Protein_1595malto-oligosyltrehalose trehalohydrolase-
FCU26_RS085651753469..1755766-2298WP_003407790.1malto-oligosyltrehalose synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T124407 WP_003407786.1 NZ_CP039850:1751314-1751718 [Mycobacterium tuberculosis variant bovis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T124407 NZ_CP039850:1751314-1751718 [Mycobacterium tuberculosis variant bovis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT124407 WP_009935474.1 NZ_CP039850:1751105-1751308 [Mycobacterium tuberculosis variant bovis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT124407 NZ_CP039850:1751105-1751308 [Mycobacterium tuberculosis variant bovis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6A7V

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E8UJ46

References