Detailed information of TA system TA124402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385879..1386567
• Replicon: chromosome
• Accession: NZ_CP039850
• Organism: Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FCU26_RS06875
• Protein ID: WP_003406304.1
• Coordinates: 1386136..1386567 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FCU26_RS06870
• Protein ID: WP_003406302.1
• Coordinates: 1385879..1386139 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCU26_RS06850	1381456..1382280	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FCU26_RS06855	1382285..1383466	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FCU26_RS06860	1383543..1384643	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FCU26_RS06865	1384814..1385803	+	990	WP_003406301.1	malate dehydrogenase	-
FCU26_RS06870	1385879..1386139	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FCU26_RS06875	1386136..1386567	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCU26_RS06880	1386590..1388278	-	1689	WP_003910308.1	PE family protein	-
FCU26_RS06890	1388458..1389318	+	861	WP_003406306.1	hypothetical protein	-
FCU26_RS06895	1389399..1390229	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FCU26_RS06900	1390286..1390579	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FCU26_RS06905	1390576..1390845	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T124402 WP_003406304.1 NZ_CP039850:1386136-1386567 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T124402 NZ_CP039850:1386136-1386567 [Mycobacterium tuberculosis variant bovis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT124402 WP_003406302.1 NZ_CP039850:1385879-1386139 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT124402 NZ_CP039850:1385879-1386139 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6