Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1025017..1025990 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag FCU26_RS05060 Protein ID WP_003404756.1
Coordinates 1025490..1025990 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag FCU26_RS05055 Protein ID WP_003404754.1
Coordinates 1025017..1025493 (+) Length 159 a.a.

Genomic Context

FCU26_RS05045FCU26_RS05050FCU26_RS05055FCU26_RS05060FCU26_RS05075FCU26_RS05080FCU26_RS05035FCU26_RS05040FCU26_RS05070
Location: 1022893..1024674 (1782 bp)
Type: Others
Protein ID: WP_003404749.1
Location: 1024671..1024928 (258 bp)
Type: Others
Protein ID: WP_003404750.1
Location: 1025017..1025493 (477 bp)
Type: Antitoxin
Protein ID: WP_003404754.1
Location: 1025490..1025990 (501 bp)
Type: Toxin
Protein ID: WP_003404756.1
Location: 1027910..1028491 (582 bp)
Type: Others
Protein ID: WP_003404760.1
Location: 1028491..1030143 (1653 bp)
Type: Others
Protein ID: WP_003404761.1
Location: 1020864..1022135 (1272 bp)
Type: Others
Protein ID: WP_003404747.1
Location: 1022150..1022449 (300 bp)
Type: Others
Protein ID: WP_003404748.1
Location: 1026303..1027622 (1320 bp)
Type: Others
Protein ID: WP_010950468.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS050351020864..1022135-1272WP_003404747.1PPE family protein-
FCU26_RS050401022150..1022449-300WP_003404748.1PE family protein-
FCU26_RS050451022893..1024674+1782WP_003404749.1BCCT family transporter-
FCU26_RS050501024671..1024928+258WP_003404750.1hypothetical protein-
FCU26_RS050551025017..1025493+477WP_003404754.1DUF1778 domain-containing proteinAntitoxin
FCU26_RS050601025490..1025990+501WP_003404756.1GNAT family N-acetyltransferaseToxin
FCU26_RS050701026303..1027622-1320WP_010950468.1IS256-like element IS1554 family transposase-
FCU26_RS050751027910..1028491+582WP_003404760.1IS607-like element IS1535 family transposase-
FCU26_RS050801028491..1030143+1653WP_003404761.1IS607 family element transposase accessory protein TnpB-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1024671..107058445913


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T124398 WP_003404756.1 NZ_CP039850:1025490-1025990 [Mycobacterium tuberculosis variant bovis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T124398 NZ_CP039850:1025490-1025990 [Mycobacterium tuberculosis variant bovis]
GTGAGCGGCTACAGCGCGCCGCGACGTATCAGCGACGCCGATGACGTCACGAGCTTCAGCAGCGGCGAGCCCAGTCTGGA
CGATTACTTGCGCAAGCGGGCGTTGGCCAACCATGTGCAGGGAGGGTCGCGCTGTTTCGTGACGTGCCGTGACGGTCGGG
TAGTCGGCTTCTATGCGCTAGCGTCAGGGTCGGTCGCACACGCTGATGCTCCGGGACGGGTGCGCCGCAATATGCCTGAC
CCCGTGCCGGTGATCCTGCTGTCGCGGTTGGCGGTTGATCGCAAAGAACAGGGCAGGGGCCTGGGCAGTCATCTGCTGCG
TGATGCGATCGGTCGCTGTGTCCAGGCTGCGGACTCGATCGGGCTGCGGGCGATTCTTGTTCATGCGTTGCACGATGAGG
CCCGCGCGTTCTACGTCCACTTCGACTTCGAGATCTCGCCGACCGATCCGCTGCACCTAATGCTGTTGATGAAAGACGCT
CGCGCGCTAATTGGCGACTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT124398 WP_003404754.1 NZ_CP039850:1025017-1025493 [Mycobacterium tuberculosis variant bovis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT124398 NZ_CP039850:1025017-1025493 [Mycobacterium tuberculosis variant bovis]
TTGCACCGAGCGGGAGCGGCGGTGACGGCCAACGTGTGGTGTCGTGCGGGCGGCATTCGGATGGCGCCACGGCCGGTCAT
CCCGGTGGCTACGCAGCAGCGCCTGCGGCGGCAGGCGGATCGCCAGAGCCTGGGTGGTAGCGGCTTGCCAGCGTTGAATT
GTACGCCTATCAGGCACACAATTGATGTCATGGCTACCAAGCCTGAGCGGAAGACCGAGCGTCTTGCAGCGCGCCTGACC
CCTGAGCAGGACGCGCTGATTCGTCGTGCTGCCGAGGCCGAGGGGACTGACCTCACCAATTTCACGGTTACAGCGGCGTT
GGCGCACGCGCGCGACGTGCTGGCCGACCGCCGGCTCTTCGTACTCACCGATGCCGCGTGGACTGAGTTCCTCGCCGCGC
TGGACCGGCCCGTCTCACACAAGCCTCGGTTGGAGAAGCTGTTCGCCGCGCGGTCCATTTTCGACACCGAGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7U4BSZ2

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBG0TFR4

References