Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754735..755368 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FCU26_RS03580 Protein ID WP_003403365.1
Coordinates 754735..755118 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag FCU26_RS03585 Protein ID WP_003403368.1
Coordinates 755213..755368 (-) Length 52 a.a.

Genomic Context

FCU26_RS03555FCU26_RS03560FCU26_RS03570FCU26_RS03575FCU26_RS03615FCU26_RS03565FCU26_RS03580FCU26_RS03585FCU26_RS03590FCU26_RS03595FCU26_RS03600FCU26_RS03605FCU26_RS03610
Location: 750027..750563 (537 bp)
Type: Others
Protein ID: WP_003403341.1
Location: 750600..750992 (393 bp)
Type: Others
Protein ID: WP_003403353.1
Location: 751751..753256 (1506 bp)
Type: Others
Protein ID: WP_003403360.1
Location: 753337..754347 (1011 bp)
Type: Others
Protein ID: WP_003911248.1
Location: 757888..760251 (2364 bp)
Type: Others
Protein ID: WP_003403397.1
Location: 750985..751680 (696 bp)
Type: Others
Protein ID: WP_003403355.1
Location: 754735..755118 (384 bp)
Type: Toxin
Protein ID: WP_003403365.1
Location: 755213..755368 (156 bp)
Type: Antitoxin
Protein ID: WP_003403368.1
Location: 755444..756160 (717 bp)
Type: Others
Protein ID: WP_003403371.1
Location: 756436..756744 (309 bp)
Type: Others
Protein ID: WP_003403376.1
Location: 756731..756976 (246 bp)
Type: Others
Protein ID: WP_003403381.1
Location: 757086..757523 (438 bp)
Type: Others
Protein ID: WP_003403386.1
Location: 757520..757774 (255 bp)
Type: Others
Protein ID: WP_003911263.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS03555750027..750563+537WP_003403341.150S ribosomal protein L10-
FCU26_RS03560750600..750992+393WP_003403353.150S ribosomal protein L7/L12-
FCU26_RS03565750985..751680-696WP_003403355.1TetR/AcrR family transcriptional regulator-
FCU26_RS03570751751..753256+1506WP_003403360.1carotenoid cleavage oxygenase-
FCU26_RS03575753337..754347+1011WP_003911248.1ABC transporter ATP-binding protein-
FCU26_RS03580754735..755118-384WP_003403365.1ribonuclease VapC6Toxin
FCU26_RS03585755213..755368-156WP_003403368.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
FCU26_RS03590755444..756160-717WP_003403371.1CPBP family intramembrane metalloprotease-
FCU26_RS03595756436..756744-309WP_003403376.1type II toxin-antitoxin system PemK/MazF family toxin-
FCU26_RS03600756731..756976-246WP_003403381.1ribbon-helix-helix protein, CopG family-
FCU26_RS03605757086..757523-438WP_003403386.1type II toxin-antitoxin system VapC family toxin-
FCU26_RS03610757520..757774-255WP_003911263.1antitoxin VapB7-
FCU26_RS03615757888..760251+2364WP_003403397.1arylsulfatase AtsD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T124392 WP_003403365.1 NZ_CP039850:c755118-754735 [Mycobacterium tuberculosis variant bovis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T124392 NZ_CP039850:c755118-754735 [Mycobacterium tuberculosis variant bovis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT124392 WP_003403368.1 NZ_CP039850:c755368-755213 [Mycobacterium tuberculosis variant bovis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT124392 NZ_CP039850:c755368-755213 [Mycobacterium tuberculosis variant bovis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBG0TQD6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BSF8

References