Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 678934..679553 Replicon chromosome
Accession NZ_CP039850
Organism Mycobacterium tuberculosis variant bovis strain Danish 1331

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag FCU26_RS03155 Protein ID WP_003403047.1
Coordinates 679146..679553 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag FCU26_RS03150 Protein ID WP_003403039.1
Coordinates 678934..679149 (+) Length 72 a.a.

Genomic Context

FCU26_RS03140FCU26_RS03150FCU26_RS03155FCU26_RS03165FCU26_RS03145FCU26_RS03160
Location: 677462..678220 (759 bp)
Type: Others
Protein ID: WP_003898511.1
Location: 678934..679149 (216 bp)
Type: Antitoxin
Protein ID: WP_003403039.1
Location: 679146..679553 (408 bp)
Type: Toxin
Protein ID: WP_003403047.1
Location: 680453..683086 (2634 bp)
Type: Others
Protein ID: WP_010950416.1
Location: 678349..678840 (492 bp)
Type: Others
Protein ID: WP_003403017.1
Location: 679613..680299 (687 bp)
Type: Others
Protein ID: WP_003403052.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FCU26_RS03140677462..678220+759WP_003898511.1Mut7-C ubiquitin/RNAse domain-containing protein-
FCU26_RS03145678349..678840-492WP_003403017.1hypothetical protein-
FCU26_RS03150678934..679149+216WP_003403039.1type II toxin-antitoxin system antitoxin VapB26Antitoxin
FCU26_RS03155679146..679553+408WP_003403047.1type II toxin-antitoxin system toxin ribonuclease C26Toxin
FCU26_RS03160679613..680299-687WP_003403052.1LpqN/LpqT family lipoprotein-
FCU26_RS03165680453..683086+2634WP_010950416.1GH92 family glycosyl hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T124385 WP_003403047.1 NZ_CP039850:679146-679553 [Mycobacterium tuberculosis variant bovis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T124385 NZ_CP039850:679146-679553 [Mycobacterium tuberculosis variant bovis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT124385 WP_003403039.1 NZ_CP039850:678934-679149 [Mycobacterium tuberculosis variant bovis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT124385 NZ_CP039850:678934-679149 [Mycobacterium tuberculosis variant bovis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5X3T

Antitoxin

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Source
ID
Structure
PDB5X3T
AlphaFold DBA0A7U4BSA2

References