Detailed information of TA system TA124378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 113228..113778
• Replicon: plasmid pAP22518-2
• Accession: NZ_CP039847
• Organism: Acetobacter pasteurianus strain CICC 22518

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: FCN51_RS14015
• Protein ID: WP_003618711.1
• Coordinates: 113228..113521 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: FCN51_RS14020
• Protein ID: WP_003618686.1
• Coordinates: 113518..113778 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN51_RS13995	108807..109532	-	726	Protein_110	ImuA family protein	-
FCN51_RS14000	109818..110516	+	699	Protein_111	DUF1275 domain-containing protein	-
FCN51_RS14005	110682..112439	+	1758	WP_006117366.1	oleate hydratase	-
FCN51_RS14010	112509..113042	-	534	WP_006117365.1	hypothetical protein	-
FCN51_RS14015	113228..113521	-	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FCN51_RS14020	113518..113778	-	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FCN51_RS14025	113992..114354	-	363	WP_012813198.1	hypothetical protein	-
FCN51_RS14030	114504..115591	+	1088	WP_114012474.1	IS3 family transposase	-
FCN51_RS14035	115632..116411	-	780	Protein_118	LysR family transcriptional regulator	-
FCN51_RS14040	116513..116773	+	261	Protein_119	SDR family NAD(P)-dependent oxidoreductase	-
FCN51_RS14045	116824..118034	+	1211	WP_096884248.1	IS3 family transposase	-
FCN51_RS14050	118034..118582	+	549	Protein_121	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..160303	160303

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-69)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 14441.32 Da
• Isoelectric Point: 5.5500

>T124378 WP_003618711.1 NZ_CP039847:c113521-113228 [Acetobacter pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 294 bp

>T124378 NZ_CP039847:c113521-113228 [Acetobacter pasteurianus]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 12822.38 Da
• Isoelectric Point: 5.5500

>AT124378 WP_003618686.1 NZ_CP039847:c113778-113518 [Acetobacter pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFF

Nucleotide

• Length: 261 bp

>AT124378 NZ_CP039847:c113778-113518 [Acetobacter pasteurianus]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6