Detailed information of TA system TA124377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 58568..59118
• Replicon: plasmid pAP22518-2
• Accession: NZ_CP039847
• Organism: Acetobacter pasteurianus strain CICC 22518

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: FCN51_RS13740
• Protein ID: WP_003618711.1
• Coordinates: 58825..59118 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: FCN51_RS13735
• Protein ID: WP_003618686.1
• Coordinates: 58568..58828 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN51_RS13715	54005..54445	+	441	WP_039891503.1	hypothetical protein	-
FCN51_RS13720	54513..55247	+	735	WP_039891505.1	class I SAM-dependent methyltransferase	-
FCN51_RS13725	56235..56702	+	468	WP_050793094.1	hypothetical protein	-
FCN51_RS13730	56902..57975	+	1074	WP_006115447.1	alkene reductase	-
FCN51_RS13735	58568..58828	+	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FCN51_RS13740	58825..59118	+	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FCN51_RS13745	59250..60512	+	1263	WP_006115449.1	sodium:proton antiporter	-
FCN51_RS13750	60512..60931	+	420	Protein_61	DUF1275 domain-containing protein	-
FCN51_RS13755	61030..61389	+	360	WP_012812356.1	transposase	-
FCN51_RS13760	61386..61733	+	348	WP_012812355.1	IS66 family insertion sequence element accessory protein TnpB	-
FCN51_RS13765	61797..63407	+	1611	WP_006115450.1	IS66 family transposase	-
FCN51_RS13770	63532..64017	-	486	WP_082823248.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..160303	160303

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 12579.08 Da
• Isoelectric Point: 12.7867

>T124377 WP_003618711.1 NZ_CP039847:58825-59118 [Acetobacter pasteurianus]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 294 bp

>T124377 NZ_CP039847:58825-59118 [Acetobacter pasteurianus]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 11169.16 Da
• Isoelectric Point: 12.7344

>AT124377 WP_003618686.1 NZ_CP039847:58568-58828 [Acetobacter pasteurianus]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKK

Nucleotide

• Length: 261 bp

>AT124377 NZ_CP039847:58568-58828 [Acetobacter pasteurianus]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6