124375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/VapC-MazE
Location 4381..5042 Replicon plasmid pAP22518-2
Accession NZ_CP039847
Organism Acetobacter pasteurianus strain CICC 22518

Toxin (Protein)


Gene name vapC Uniprot ID C7JIL1
Locus tag FCN51_RS13485 Protein ID WP_006115553.1
Coordinates 4734..5042 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID C7JIL0
Locus tag FCN51_RS13480 Protein ID WP_006115554.1
Coordinates 4381..4635 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN51_RS13445 742..1590 + 849 WP_039891563.1 hypothetical protein -
FCN51_RS13450 1593..2057 + 465 WP_039891560.1 hypothetical protein -
FCN51_RS13455 2154..2969 + 816 WP_006115558.1 hypothetical protein -
FCN51_RS13460 2982..3386 + 405 WP_006115557.1 hypothetical protein -
FCN51_RS13465 3443..3763 - 321 WP_012813211.1 hypothetical protein -
FCN51_RS13470 3793..3993 - 201 WP_012813212.1 hypothetical protein -
FCN51_RS13475 4050..4379 - 330 WP_012813213.1 endoribonuclease MazF -
FCN51_RS13480 4381..4635 - 255 WP_006115554.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FCN51_RS13485 4734..5042 - 309 WP_006115553.1 PIN domain-containing protein Toxin
FCN51_RS13490 5039..5311 - 273 WP_006115552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FCN51_RS13495 5384..5644 - 261 Protein_11 hypothetical protein -
FCN51_RS13500 5702..6661 + 960 WP_035350857.1 IS481 family transposase -
FCN51_RS13510 7097..8530 + 1434 WP_006115551.1 cytochrome ubiquinol oxidase subunit I -
FCN51_RS13515 8533..9552 + 1020 WP_006115550.1 cytochrome d ubiquinol oxidase subunit II -
FCN51_RS13520 9539..9688 + 150 WP_007397858.1 DUF2474 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..160303 160303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 15177.21 Da        Isoelectric Point: 5.5500

>T124375 WP_006115553.1 NZ_CP039847:c5042-4734 [Acetobacter pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 309 bp

>T124375 NZ_CP039847:c5042-4734 [Acetobacter pasteurianus]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 12528.03 Da        Isoelectric Point: 5.5500

>AT124375 WP_006115554.1 NZ_CP039847:c4635-4381 [Acetobacter pasteurianus]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFF

Download         Length: 255 bp

>AT124375 NZ_CP039847:c4635-4381 [Acetobacter pasteurianus]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401X8Y0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1QDC4

References