Detailed information of TA system TA124371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 4269247..4269832
• Replicon: chromosome
• Accession: NZ_CP039844
• Organism: Providencia rettgeri strain Pr-15-2-50

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FCT01_RS19685
• Protein ID: WP_110591061.1
• Coordinates: 4269247..4269564 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4C3P0
• Locus tag: FCT01_RS19690
• Protein ID: WP_004905876.1
• Coordinates: 4269545..4269832 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCT01_RS19655	4264950..4265201	-	252	WP_110591062.1	DUF1471 domain-containing protein	-
FCT01_RS19660	4265472..4265810	+	339	WP_004905864.1	GIY-YIG nuclease family protein	-
FCT01_RS19665	4265783..4266286	-	504	WP_004905865.1	N-acetyltransferase	-
FCT01_RS19670	4266280..4266804	-	525	WP_004905868.1	SCP2 domain-containing protein	-
FCT01_RS19675	4267319..4268314	+	996	WP_094961644.1	U32 family peptidase	-
FCT01_RS19680	4268332..4269207	+	876	WP_096864325.1	U32 family peptidase	-
FCT01_RS19685	4269247..4269564	-	318	WP_110591061.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FCT01_RS19690	4269545..4269832	-	288	WP_004905876.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FCT01_RS19695	4269963..4271117	-	1155	WP_004905877.1	ABC transporter permease	-
FCT01_RS19700	4271117..4272262	-	1146	WP_004905879.1	ABC transporter permease	-
FCT01_RS19705	4272274..4273245	-	972	WP_110591060.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (14-104)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-75)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12206.90 Da
• Isoelectric Point: 8.4953

>T124371 WP_110591061.1 NZ_CP039844:c4269564-4269247 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKESWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Nucleotide

• Length: 318 bp

>T124371 NZ_CP039844:c4269564-4269247 [Providencia rettgeri]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGGAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10763.44 Da
• Isoelectric Point: 5.8809

>AT124371 WP_004905876.1 NZ_CP039844:c4269832-4269545 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Nucleotide

• Length: 288 bp

>AT124371 NZ_CP039844:c4269832-4269545 [Providencia rettgeri]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAACAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TAAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A345M0A6