Detailed information of TA system TA124368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2489836..2490752
• Replicon: chromosome
• Accession: NZ_CP039844
• Organism: Providencia rettgeri strain Pr-15-2-50

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FCT01_RS11260
• Protein ID: WP_110591697.1
• Coordinates: 2490294..2490752 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D4BTW8
• Locus tag: FCT01_RS11255
• Protein ID: WP_004254502.1
• Coordinates: 2489836..2490297 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCT01_RS11225	2485502..2486116	+	615	WP_110591700.1	LysE family translocator	-
FCT01_RS11230	2486140..2486613	-	474	WP_096863737.1	NUDIX domain-containing protein	-
FCT01_RS11235	2486965..2487606	-	642	WP_004254492.1	leucine efflux protein LeuE	-
FCT01_RS11240	2488080..2488781	+	702	WP_004254495.1	AzlC family ABC transporter permease	-
FCT01_RS11245	2488778..2489092	+	315	WP_094960595.1	AzlD domain-containing protein	-
FCT01_RS11250	2489280..2489747	+	468	WP_110591698.1	DUF1456 family protein	-
FCT01_RS11255	2489836..2490297	+	462	WP_004254502.1	DUF2384 domain-containing protein	Antitoxin
FCT01_RS11260	2490294..2490752	+	459	WP_110591697.1	RES domain-containing protein	Toxin
FCT01_RS11265	2490753..2491643	-	891	WP_094960598.1	LysR family transcriptional regulator	-
FCT01_RS11270	2491689..2492650	-	962	Protein_2210	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
FCT01_RS11275	2492756..2493178	-	423	WP_110591696.1	helix-turn-helix domain-containing protein	-
FCT01_RS11280	2493209..2493772	-	564	WP_004254518.1	GNAT family N-acetyltransferase	-
FCT01_RS11285	2493753..2495219	-	1467	WP_094960601.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17074.62 Da
• Isoelectric Point: 6.2048

>T124368 WP_110591697.1 NZ_CP039844:2490294-2490752 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEVLVHINQDILLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Nucleotide

• Length: 459 bp

>T124368 NZ_CP039844:2490294-2490752 [Providencia rettgeri]
ATGATTTTATATCGATTGGTTAAATCCAATTTTGCGCATGATGCATGGTCGGGCCAAGGAGCTATGCTCTACGGCGGGCG
TTGGAATCATAAAGGGACTCCTGCTGTTTATACTTCAACGAGTATTTCATTAGCGACCCTTGAAGTACTCGTTCACATCA
ATCAAGACATACTATTAAGCCAGTTCAGCTTACTATCCATAGATATCAATGATAAGTACGTGATGAAATTGTCGTTAGAT
CACCTTCCGACAGATTGGCAACAAGACCCCGCACCAACCTCCACCATGGATATTGGCACTATATGGCTTAATAACCAAGA
TAGTCTAGCATTATTAATTCCCTCTTGTATTGTTCCCTATGAATACAACGCAATTATTAACCCGTTACATCCGCAATTTC
AAAAAGCTTTACATACCGTTAAACCACTAGATTTTAGTGTTGACCCGCGCTTAGCATAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17090.56 Da
• Isoelectric Point: 9.9140

>AT124368 WP_004254502.1 NZ_CP039844:2489836-2490297 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT124368 NZ_CP039844:2489836-2490297 [Providencia rettgeri]
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCCTTTAAACCACTGTGGCGCCATGTAGGGTTACC
CGCAGAACGTGGTATTGAGTTAACTCATTTCTTGCGTCAAGGCCTATCTGTCTCTGTCTTAGACAATATCCAAGAATGGT
CAGGAATGAGCAAAACTGAATTATTGCGAATATCCGGCATTAATGAGCGCAATATTGCTCGACGTAAAAATGCTGGCCAG
CCCCTTAATGCTGATGAAAGTGAGAGAATTGCTCGTCTAGTGCGGGTATTCGATGCTGCGGTGCGTTTATTTAATGGAGA
TAAGCACGCGGCAAGTGATTGGCTTAACCACCCAGTTAAAGGGTTAGGACATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGCGGAGCCATTGAAGTGATTGATTTGATTGGCCGTATTGAACATGGCGTATTCTCATGA

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q7V6