Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1826853..1827501 Replicon chromosome
Accession NZ_CP039844
Organism Providencia rettgeri strain Pr-15-2-50

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FCT01_RS08215 Protein ID WP_094961724.1
Coordinates 1827316..1827501 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FCT01_RS08210 Protein ID WP_094961723.1
Coordinates 1826853..1827266 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCT01_RS08185 1822168..1823304 - 1137 WP_036958991.1 M4 family metallopeptidase -
FCT01_RS08190 1823463..1824380 - 918 WP_004264888.1 oxygen-dependent coproporphyrinogen oxidase -
FCT01_RS08195 1824517..1824948 + 432 WP_110591954.1 GNAT family acetyltransferase -
FCT01_RS08200 1825040..1825645 + 606 WP_110591953.1 RpoE-regulated lipoprotein -
FCT01_RS08205 1825888..1826787 + 900 WP_094961722.1 Dyp-type peroxidase -
FCT01_RS08210 1826853..1827266 - 414 WP_094961723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FCT01_RS08215 1827316..1827501 - 186 WP_094961724.1 type II toxin-antitoxin system HicA family toxin Toxin
FCT01_RS08220 1827824..1828846 + 1023 WP_094961725.1 sulfate ABC transporter substrate-binding protein -
FCT01_RS08225 1828846..1829676 + 831 WP_004264883.1 sulfate/thiosulfate ABC transporter permease CysT -
FCT01_RS08230 1829676..1830536 + 861 WP_004264881.1 sulfate/thiosulfate ABC transporter permease CysW -
FCT01_RS08235 1830539..1831627 + 1089 WP_110591952.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6992.20 Da        Isoelectric Point: 11.0146

>T124367 WP_094961724.1 NZ_CP039844:c1827501-1827316 [Providencia rettgeri]
VQSSELINILQKNGWKLERIKGSHHQFSHPHFSIVITVPHPQKDLKIGTLNHILKAAKLKH

Download         Length: 186 bp

>T124367 NZ_CP039844:c1827501-1827316 [Providencia rettgeri]
GTGCAAAGTTCGGAACTGATAAACATACTGCAAAAAAACGGTTGGAAACTTGAAAGAATAAAAGGAAGTCACCATCAGTT
TTCCCACCCACATTTTTCAATTGTAATTACTGTTCCGCATCCACAAAAAGATTTAAAGATAGGCACACTAAATCACATTT
TGAAGGCTGCGAAACTAAAACATTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15362.31 Da        Isoelectric Point: 4.6719

>AT124367 WP_094961723.1 NZ_CP039844:c1827266-1826853 [Providencia rettgeri]
MLYTAFIEIDNDGSASGWFPDIEGCTFAGSNIEEAYAEAKSAIDAHFELLSEKGFEIPLSKSQQTLLNPIQPEYAHGIWL
FVDVDMDKYDGRTERINITLPHRLLHRIDALVKVNPEYGSRSGFIAAAARKELKKTD

Download         Length: 414 bp

>AT124367 NZ_CP039844:c1827266-1826853 [Providencia rettgeri]
ATGCTTTATACCGCCTTTATTGAAATTGATAATGATGGCAGCGCAAGTGGCTGGTTTCCTGATATTGAAGGATGTACATT
CGCGGGCAGCAATATAGAAGAGGCTTACGCAGAAGCAAAATCAGCAATTGATGCTCATTTTGAATTATTGAGTGAAAAAG
GCTTTGAGATCCCATTATCGAAATCTCAGCAAACGCTATTGAACCCAATACAACCTGAATATGCGCATGGGATATGGTTA
TTTGTGGATGTCGATATGGATAAATACGATGGCCGTACTGAGCGTATTAATATCACCTTGCCGCATCGTTTATTACATCG
TATTGATGCTTTAGTGAAGGTTAATCCTGAATATGGTAGCCGTAGTGGTTTTATTGCTGCTGCAGCTCGTAAAGAATTAA
AAAAAACCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References