Detailed information of TA system TA124366

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1537747..1538404
• Replicon: chromosome
• Accession: NZ_CP039844
• Organism: Providencia rettgeri strain Pr-15-2-50

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FCT01_RS06845
• Protein ID: WP_110592138.1
• Coordinates: 1537994..1538404 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D4C097
• Locus tag: FCT01_RS06840
• Protein ID: WP_004261864.1
• Coordinates: 1537747..1538013 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCT01_RS06825	1534743..1535639	-	897	WP_165119666.1	hypothetical protein	-
FCT01_RS06830	1535884..1536504	-	621	WP_004261871.1	HD domain-containing protein	-
FCT01_RS06835	1536516..1537499	-	984	WP_110592139.1	tRNA-modifying protein YgfZ	-
FCT01_RS06840	1537747..1538013	+	267	WP_004261864.1	FAD assembly factor SdhE	Antitoxin
FCT01_RS06845	1537994..1538404	+	411	WP_110592138.1	protein YgfX	Toxin
FCT01_RS06850	1538504..1539022	-	519	WP_004261816.1	flavodoxin FldB	-
FCT01_RS06855	1539140..1540042	+	903	WP_004261814.1	site-specific tyrosine recombinase XerD	-
FCT01_RS06860	1540064..1540768	+	705	WP_096863312.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FCT01_RS06865	1540778..1542511	+	1734	WP_110592137.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15602.55 Da
• Isoelectric Point: 10.7733

>T124366 WP_110592138.1 NZ_CP039844:1537994-1538404 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLAPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWRILKAPWFTRYGILLTLEALQGKPQKLHLWVAKDALSEENWRNLNQLLLQYPDI

Nucleotide

• Length: 411 bp

>T124366 NZ_CP039844:1537994-1538404 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACCCAACTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTACTATTGGCTCCATGGTCCCCTGGTAACTCAATGATATGGTTGCCGCTATTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGTCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGTAATAAGGTTCAGTGGAAGAAAAAT
GAATGGAGAATACTGAAAGCACCTTGGTTTACCCGCTATGGTATATTACTGACACTAGAAGCGTTACAAGGTAAACCACA
AAAGCTCCATTTGTGGGTTGCAAAAGACGCATTGTCGGAAGAGAATTGGCGTAATTTAAACCAATTATTGCTGCAATACC
CTGATATTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.24 Da
• Isoelectric Point: 4.8942

>AT124366 WP_004261864.1 NZ_CP039844:1537747-1538013 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Nucleotide

• Length: 267 bp

>AT124366 NZ_CP039844:1537747-1538013 [Providencia rettgeri]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATGACCTAACAACTCACGATAAGCAGGTATTTGTCCGTTTATTAGAATGTGCGGACCCTGATT
TATTCAATTGGCTAATGAATCACGGTCGTCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Structures

Antitoxin

• AlphaFold DB: A0A345M2Q5