Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 891869..892515 Replicon chromosome
Accession NZ_CP039844
Organism Providencia rettgeri strain Pr-15-2-50

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag FCT01_RS03940 Protein ID WP_004905417.1
Coordinates 891869..892072 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag FCT01_RS03945 Protein ID WP_004905413.1
Coordinates 892147..892515 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCT01_RS03915 887945..888283 + 339 WP_004905421.1 P-II family nitrogen regulator -
FCT01_RS03920 888294..889580 + 1287 WP_004905420.1 ammonium transporter AmtB -
FCT01_RS03925 889719..890588 - 870 WP_036958583.1 acyl-CoA thioesterase II -
FCT01_RS03930 890827..891285 + 459 WP_004905418.1 YbaY family lipoprotein -
FCT01_RS03940 891869..892072 - 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
FCT01_RS03945 892147..892515 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
FCT01_RS03950 893039..894409 - 1371 WP_110592389.1 murein transglycosylase D -
FCT01_RS03955 894491..895246 - 756 WP_110592388.1 hydroxyacylglutathione hydrolase -
FCT01_RS03960 895287..896021 + 735 WP_110592387.1 methyltransferase domain-containing protein -
FCT01_RS03965 896018..896488 - 471 WP_004905405.1 ribonuclease HI -
FCT01_RS03970 896543..897304 + 762 WP_094962150.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T124365 WP_004905417.1 NZ_CP039844:c892072-891869 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T124365 NZ_CP039844:c892072-891869 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACCACAATTGAAACACTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCAGCAGATCACCGCTTAGCTGAACTCACAATGAATAAGC
TTTATGATAAAATCCCAGCGTCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT124365 WP_004905413.1 NZ_CP039844:c892515-892147 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT124365 NZ_CP039844:c892515-892147 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAATAGTCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTCATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATACCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAATACCTC
GATGAGACCTATGATTTATTCGGCAGCCCAGTTATCACACTTAGTGAAATTATAGACTGGGAAGCAATGAATCACAGCCT
TGTCGCTGTGCTGGATGATGACCTAAAGTGCCTAACCAGCAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References