Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 50091..50626 Replicon plasmid pUSDA5905_2
Accession NZ_CP039842
Organism Escherichia coli O157:H7 strain USDA5905

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E3175_RS26955 Protein ID WP_001270421.1
Coordinates 50091..50378 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E3175_RS26960 Protein ID WP_001132894.1
Coordinates 50375..50626 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3175_RS26915 45494..45673 - 180 WP_000526857.1 hypothetical protein -
E3175_RS26920 45876..46250 + 375 WP_001368887.1 hypothetical protein -
E3175_RS26925 46561..46722 - 162 Protein_57 epoxyqueuosine reductase QueH -
E3175_RS26930 46773..46913 + 141 Protein_58 serine/threonine protein kinase -
E3175_RS26935 47037..47777 + 741 WP_001066926.1 tyrosine-type recombinase/integrase -
E3175_RS26940 48061..49038 - 978 WP_000361616.1 RepB family plasmid replication initiator protein -
E3175_RS26945 49446..49595 - 150 WP_001483821.1 hypothetical protein -
E3175_RS26950 49684..50089 - 406 Protein_62 DDE-type integrase/transposase/recombinase -
E3175_RS26955 50091..50378 - 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3175_RS26960 50375..50626 - 252 WP_001132894.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3175_RS26965 51015..52220 + 1206 WP_000817637.1 AAA family ATPase -
E3175_RS26970 52217..53179 + 963 WP_000756329.1 ParB/RepB/Spo0J family partition protein -
E3175_RS26975 53320..54331 - 1012 Protein_67 DUF4113 domain-containing protein -
E3175_RS26980 54362..54778 + 417 Protein_68 DUF1281 domain-containing protein -
E3175_RS26985 54782..55087 + 306 WP_032163448.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - stcE / exeE / exeG / nleA/espI 1..62787 62787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T124363 WP_001270421.1 NZ_CP039842:c50378-50091 [Escherichia coli O157:H7]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T124363 NZ_CP039842:c50378-50091 [Escherichia coli O157:H7]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTAGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAG
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9220.55 Da        Isoelectric Point: 4.2108

>AT124363 WP_001132894.1 NZ_CP039842:c50626-50375 [Escherichia coli O157:H7]
MPNIILSDTSASVSELKKNPMATVSAGDGFPIAILNRNQPVFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT124363 NZ_CP039842:c50626-50375 [Escherichia coli O157:H7]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGATCGCTATCCTGAACCGTAATCAGCCTGTTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTAGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References