Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3574330..3574808 Replicon chromosome
Accession NZ_CP039834
Organism Escherichia coli O157:H7 strain MB41-1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FCV42_RS18440 Protein ID WP_001303876.1
Coordinates 3574521..3574808 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FCV42_RS18435 Protein ID WP_000536233.1
Coordinates 3574330..3574521 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCV42_RS18400 3569734..3570504 - 771 WP_000450992.1 DUF1627 domain-containing protein -
FCV42_RS18405 3570526..3571272 - 747 WP_000788751.1 ATP-binding protein -
FCV42_RS18410 3571279..3572370 - 1092 WP_001205823.1 hypothetical protein -
FCV42_RS18415 3572449..3572904 + 456 WP_000273724.1 hypothetical protein -
FCV42_RS18420 3573111..3573536 - 426 WP_000693855.1 Rha family transcriptional regulator -
FCV42_RS18425 3573520..3573792 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FCV42_RS18430 3573901..3574302 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FCV42_RS18435 3574330..3574521 + 192 WP_000536233.1 hypothetical protein Antitoxin
FCV42_RS18440 3574521..3574808 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FCV42_RS18445 3575086..3575241 + 156 WP_000379575.1 DUF1391 family protein -
FCV42_RS18450 3575383..3575772 + 390 WP_000394511.1 hypothetical protein -
FCV42_RS18455 3575959..3576144 - 186 WP_001133046.1 hypothetical protein -
FCV42_RS18460 3576718..3576906 + 189 WP_000413705.1 cell division inhibition protein DicB -
FCV42_RS18465 3576903..3577094 + 192 WP_001098307.1 DUF1482 family protein -
FCV42_RS18470 3577188..3579659 + 2472 WP_000034474.1 exonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T124324 WP_001303876.1 NZ_CP039834:3574521-3574808 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T124324 NZ_CP039834:3574521-3574808 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT124324 WP_000536233.1 NZ_CP039834:3574330-3574521 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT124324 NZ_CP039834:3574330-3574521 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References