Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 156762..157297 Replicon plasmid pC3001-3
Accession NZ_CP039793
Organism Klebsiella quasipneumoniae strain C3001

Toxin (Protein)


Gene name relE Uniprot ID A0A2A5MBV5
Locus tag FA956_RS28675 Protein ID WP_032420954.1
Coordinates 157010..157297 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A5MCI9
Locus tag FA956_RS28670 Protein ID WP_032420955.1
Coordinates 156762..157013 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA956_RS28655 153577..154797 - 1221 WP_048269927.1 ISL3-like element ISCfr12 family transposase -
FA956_RS28660 154899..155324 + 426 WP_001776124.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
FA956_RS28665 155324..156595 + 1272 WP_032420957.1 Y-family DNA polymerase -
FA956_RS28670 156762..157013 + 252 WP_032420955.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FA956_RS28675 157010..157297 + 288 WP_032420954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FA956_RS28680 157304..157453 + 150 WP_158238164.1 hypothetical protein -
FA956_RS28685 157474..157752 + 279 WP_032420952.1 hypothetical protein -
FA956_RS28690 158054..158800 - 747 WP_032420989.1 hypothetical protein -
FA956_RS28695 159019..160143 - 1125 WP_096834042.1 hypothetical protein -
FA956_RS28700 160793..161185 - 393 WP_032420949.1 plasmid partitioning/stability family protein -
FA956_RS28705 161189..162163 - 975 WP_032752080.1 StbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / tet(D) / catA2 / aac(3)-IId / blaTEM-1B / blaLAP-2 / qnrS1 / aph(6)-Id / aph(3'')-Ib / sul2 pla 1..206406 206406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.13 Da        Isoelectric Point: 10.2246

>T124248 WP_032420954.1 NZ_CP039793:157010-157297 [Klebsiella quasipneumoniae]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDHLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T124248 NZ_CP039793:157010-157297 [Klebsiella quasipneumoniae]
ATGACTTATACGGTCAAATTCAGGGAAGATGCTCTGAAAGAATGGCAAAAGCTGGATAAGGCCATTCAGCAGCAGTTTGC
GAAGAAACTGAAGAAGTGCTGTGACGAACCGCATATCCCCTCAGCAAAGCTGAGAGGGATAAAGGACTGCTATAAAATTA
AACTTCGTGCATCTGGTTTTCGCCTAGTATATCAGGTGATAGATGATCATTTAATTATCGCAGTTGTTGCTGTAGGAAAG
CGTGAGCGTAGTGACGTGTACAATCTGGCCAGCGAAAGGATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9192.47 Da        Isoelectric Point: 3.9507

>AT124248 WP_032420955.1 NZ_CP039793:156762-157013 [Klebsiella quasipneumoniae]
MPNIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDAMDDQELAKLVSERSNQQLLDVDLD
TYL

Download         Length: 252 bp

>AT124248 NZ_CP039793:156762-157013 [Klebsiella quasipneumoniae]
ATGCCCAACATTATTCTGAGTGACACAAGCGCGAGCATAAGCGAACTTAAAAAAAACCCGATGGCGACAGTCAGTGCCGG
CGACGGCTTCCCGGTCGCTATTCTGAACCGTAACCAACCCGCTTTTTACTGTATCCCGGCAGAGCTTTACGAGAAGATGC
TTGATGCCATGGATGATCAGGAACTGGCAAAGCTGGTTTCAGAACGCAGTAATCAGCAGCTGCTTGACGTGGATCTGGAC
ACTTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBV5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MCI9

References