Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4102991..4103610 Replicon chromosome
Accession NZ_CP039791
Organism Klebsiella quasipneumoniae strain C3001

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FA956_RS20400 Protein ID WP_002892050.1
Coordinates 4103392..4103610 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FA956_RS20395 Protein ID WP_002892066.1
Coordinates 4102991..4103365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA956_RS20385 4098145..4099338 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FA956_RS20390 4099361..4102507 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit -
FA956_RS20395 4102991..4103365 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FA956_RS20400 4103392..4103610 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FA956_RS20405 4103769..4104335 + 567 WP_023288643.1 maltose O-acetyltransferase -
FA956_RS20410 4104307..4104438 - 132 WP_032428629.1 hypothetical protein -
FA956_RS20415 4104472..4104942 + 471 WP_023288642.1 YlaC family protein -
FA956_RS20420 4104911..4106368 - 1458 WP_101862458.1 PLP-dependent aminotransferase family protein -
FA956_RS20425 4106469..4107167 + 699 WP_101862457.1 GNAT family N-acetyltransferase -
FA956_RS20430 4107164..4107304 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FA956_RS20435 4107304..4107567 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T124245 WP_002892050.1 NZ_CP039791:4103392-4103610 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T124245 NZ_CP039791:4103392-4103610 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT124245 WP_002892066.1 NZ_CP039791:4102991-4103365 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT124245 NZ_CP039791:4102991-4103365 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACGTTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References