Detailed information of TA system TA124234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1472703..1473185
• Replicon: chromosome
• Accession: NZ_CP039740
• Organism: Pseudolabrys sp. FHR47

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E8Q40_RS07285
• Protein ID: WP_137043752.1
• Coordinates: 1472991..1473185 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: E8Q40_RS07280
• Protein ID: WP_137043751.1
• Coordinates: 1472703..1472987 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8Q40_RS07255	1468323..1469111	-	789	WP_137043746.1	L,D-transpeptidase	-
E8Q40_RS07260	1469367..1469726	+	360	WP_137043747.1	hypothetical protein	-
E8Q40_RS07265	1469918..1470316	-	399	WP_168197762.1	CAP domain-containing protein	-
E8Q40_RS07270	1470402..1472117	+	1716	WP_137043749.1	RNA-directed DNA polymerase	-
E8Q40_RS07275	1472193..1472699	+	507	WP_137043750.1	lipocalin-like domain-containing protein	-
E8Q40_RS07280	1472703..1472987	-	285	WP_137043751.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E8Q40_RS07285	1472991..1473185	-	195	WP_137043752.1	type II toxin-antitoxin system HicA family toxin	Toxin
E8Q40_RS07290	1473513..1476014	-	2502	WP_168197763.1	UvrD-helicase domain-containing protein	-
E8Q40_RS07295	1476133..1476624	-	492	WP_137043753.1	thioesterase family protein	-
E8Q40_RS07300	1476705..1478144	+	1440	WP_137043754.1	YcjX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7534.89 Da
• Isoelectric Point: 11.5878

>T124234 WP_137043752.1 NZ_CP039740:c1473185-1472991 [Pseudolabrys sp. FHR47]
MLRDSRDIIRRLLNEGFEQVSVRGSHHKFVHKAKRLMVIVAHPKRDIPVGTVRSIYKMANWPKD

Nucleotide

• Length: 195 bp

>T124234 NZ_CP039740:c1473185-1472991 [Pseudolabrys sp. FHR47]
ATGCTTCGGGACAGCCGTGATATCATCCGCCGGTTGCTAAACGAGGGGTTCGAGCAGGTGTCGGTGCGCGGTTCGCACCA
CAAGTTCGTTCACAAAGCAAAGCGTCTTATGGTCATTGTGGCGCACCCGAAACGGGACATTCCTGTTGGGACCGTACGAA
GCATCTACAAGATGGCCAACTGGCCGAAGGACTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10179.26 Da
• Isoelectric Point: 3.9293

>AT124234 WP_137043751.1 NZ_CP039740:c1472987-1472703 [Pseudolabrys sp. FHR47]
MPHYIALIHKEADSSYGVSFPDIPGVITGGDTIDEAMSMAREVLEFAAEDWDGDNRFPAPRTIDELRADPEFQADAADAV
VAAVPFRVKAEAAE

Nucleotide

• Length: 285 bp

>AT124234 NZ_CP039740:c1472987-1472703 [Pseudolabrys sp. FHR47]
ATGCCGCACTACATCGCTCTTATTCACAAGGAAGCGGATAGCTCCTACGGCGTGTCGTTTCCCGACATTCCCGGTGTGAT
TACCGGAGGCGATACAATCGACGAGGCTATGAGCATGGCCCGCGAAGTGCTGGAATTTGCCGCCGAGGATTGGGACGGCG
ACAACCGATTTCCTGCGCCCCGCACTATCGACGAGCTTCGGGCCGATCCGGAGTTTCAAGCCGATGCCGCGGACGCCGTC
GTCGCCGCCGTGCCATTTCGCGTGAAGGCCGAAGCCGCAGAGTGA