Detailed information of TA system TA124233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1441221..1441696
• Replicon: chromosome
• Accession: NZ_CP039736
• Organism: Leuconostoc sp. LN180020

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FAZ25_RS07405
• Protein ID: WP_036058531.1
• Coordinates: 1441433..1441696 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7L8V129
• Locus tag: FAZ25_RS07400
• Protein ID: WP_004903014.1
• Coordinates: 1441221..1441436 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAZ25_RS07370	1436414..1436893	-	480	WP_004903001.1	hypothetical protein	-
FAZ25_RS07375	1436904..1439156	-	2253	WP_004903003.1	toprim domain-containing protein	-
FAZ25_RS07380	1439153..1439413	-	261	WP_004903004.1	hypothetical protein	-
FAZ25_RS07385	1439871..1440254	+	384	WP_004903008.1	hypothetical protein	-
FAZ25_RS07390	1440265..1440633	+	369	WP_004903009.1	hypothetical protein	-
FAZ25_RS07395	1440640..1441161	+	522	WP_004903011.1	hypothetical protein	-
FAZ25_RS07400	1441221..1441436	+	216	WP_004903014.1	hypothetical protein	Antitoxin
FAZ25_RS07405	1441433..1441696	+	264	WP_036058531.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FAZ25_RS07410	1442111..1442341	+	231	WP_004903019.1	hypothetical protein	-
FAZ25_RS07415	1442338..1442784	+	447	WP_004903021.1	hypothetical protein	-
FAZ25_RS07420	1442768..1443091	+	324	WP_004903022.1	hypothetical protein	-
FAZ25_RS07425	1443113..1443331	+	219	WP_004903024.1	hypothetical protein	-
FAZ25_RS07430	1443796..1444047	+	252	WP_004903031.1	hypothetical protein	-
FAZ25_RS07435	1444010..1444321	+	312	WP_036069642.1	hypothetical protein	-
FAZ25_RS07440	1445008..1445259	-	252	WP_004903043.1	hypothetical protein	-
FAZ25_RS07445	1445252..1445620	-	369	WP_004903045.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	gnd	1311971..1449117	137146

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10312.79 Da
• Isoelectric Point: 10.1260

>T124233 WP_036058531.1 NZ_CP039736:1441433-1441696 [Leuconostoc sp. LN180020]
IMYRVTFTKQALKQLKKLDKFTQSTIYQWLQKNLDGTDNPRAHGKGLTANHSGEWRYRVGDYRILANIKDDEIIIEVFTI
GHRRDIY

Nucleotide

• Length: 264 bp

>T124233 NZ_CP039736:1441433-1441696 [Leuconostoc sp. LN180020]
ATAATGTATCGTGTTACTTTCACTAAACAAGCGCTTAAACAATTAAAAAAGTTAGATAAATTCACGCAAAGCACCATTTA
TCAATGGCTTCAAAAAAATCTGGACGGCACGGATAACCCACGTGCGCATGGAAAAGGATTAACCGCAAATCATTCAGGAG
AATGGCGTTACCGGGTTGGCGATTATCGTATTTTAGCCAACATTAAAGATGATGAAATTATCATTGAGGTATTCACCATT
GGGCATCGTCGCGATATTTACTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8159.38 Da
• Isoelectric Point: 4.4550

>AT124233 WP_004903014.1 NZ_CP039736:1441221-1441436 [Leuconostoc sp. LN180020]
MTTMTLRINQEDSELIKKFAATHDLSLSDFARQAMLEKIEDDYDIVELKKAMMADDGTRYTMAEVKKELGL

Nucleotide

• Length: 216 bp

>AT124233 NZ_CP039736:1441221-1441436 [Leuconostoc sp. LN180020]
ATGACAACAATGACACTACGTATCAATCAAGAAGACTCAGAGCTCATCAAGAAGTTTGCAGCAACTCATGATTTAAGTTT
ATCTGACTTCGCGCGTCAAGCTATGTTAGAAAAAATTGAAGATGATTATGATATTGTCGAATTGAAAAAAGCAATGATGG
CTGATGATGGCACGCGATATACTATGGCTGAAGTCAAAAAGGAATTAGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7L8V129