Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 297123..297759 Replicon chromosome
Accession NZ_CP039727
Organism Bacillus sp. S3

Toxin (Protein)


Gene name mazF Uniprot ID K6DRS5
Locus tag FAY30_RS01470 Protein ID WP_007083556.1
Coordinates 297409..297759 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1S2RGM2
Locus tag FAY30_RS01465 Protein ID WP_071354167.1
Coordinates 297123..297404 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAY30_RS01445 293240..293968 - 729 WP_149868233.1 rhomboid family intramembrane serine protease -
FAY30_RS01450 294062..294415 + 354 WP_149868234.1 holo-ACP synthase -
FAY30_RS01455 294577..295590 + 1014 WP_149868235.1 outer membrane lipoprotein carrier protein LolA -
FAY30_RS01460 295697..296854 + 1158 WP_149868236.1 alanine racemase -
FAY30_RS01465 297123..297404 + 282 WP_071354167.1 antitoxin endoai Antitoxin
FAY30_RS01470 297409..297759 + 351 WP_007083556.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FAY30_RS01475 298133..300319 + 2187 WP_149868237.1 RNA-binding transcriptional accessory protein -
FAY30_RS01480 300395..300508 - 114 WP_007083554.1 cortex morphogenetic protein CmpA -
FAY30_RS01485 300606..301079 + 474 WP_149868238.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T124230 WP_007083556.1 NZ_CP039727:297409-297759 [Bacillus sp. S3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

>T124230 NZ_CP039727:297409-297759 [Bacillus sp. S3]
TTGATTGTCAAGCGTGGTGACGTATATTTCGCGGACCTATCCCCAGTTGTTGGTTCTGAACAAGGCGGCGTCCGACCTGT
ACTTGTCATCCAAAATGACATCGGGAATCGGTTTAGTCCCACAGTTATTGTTGCAGCGATTACAGCTCAAATTCAAAAAG
CGAAGCTTCCTACGCATGTAGAGATTGATGCCAAGCGCTACGGATTTGAACGAGATTCGGTCATTCTGTTAGAGCAGATT
CGTACAATTGATAAGCAGCGGTTAACCGATAAAATCACTCATCTCGATGACGAAATGATGGAGAAAGTGGATGAAGCCTT
GCAGGTAAGCTTGGGTCTCATCGAATTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10836.38 Da        Isoelectric Point: 8.4664

>AT124230 WP_071354167.1 NZ_CP039727:297123-297404 [Bacillus sp. S3]
VSESGATTEILVKLPQHLLTELDGFVKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLRIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT124230 NZ_CP039727:297123-297404 [Bacillus sp. S3]
GTGTCAGAATCCGGCGCAACTACGGAAATCTTAGTGAAGTTACCGCAACATCTTTTAACTGAGTTAGATGGTTTCGTTAA
GCAAGAAAATGTAAACCGCAGCGAGTTTATTTACCAAGCAACAAAAATGTATTTACGCGAACGAAAAAAGAGACAAATTC
GCGAGTCGATGAGACGTGGATACATGGAAATGGCAAAGATAAATCTTAGAATTGCATCAGAAGCATTTCAAGCAGAATAT
GAGGCAGAACATACTGTAGAACGTCTTGTAAGCGGAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6DRS5

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2RGM2

References