Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1564600..1565578 Replicon chromosome
Accession NZ_CP039721
Organism Bacillus thuringiensis strain BT-59

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag FBF59_RS07965 Protein ID WP_000624969.1
Coordinates 1564841..1565578 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag FBF59_RS07960 Protein ID WP_000237817.1
Coordinates 1564600..1564728 (-) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF59_RS07930 1560117..1560368 + 252 WP_000821942.1 response regulator transcription factor -
FBF59_RS07935 1560509..1561114 - 606 WP_000527414.1 hypothetical protein -
FBF59_RS07940 1561140..1561949 - 810 WP_000678376.1 C39 family peptidase -
FBF59_RS07945 1562262..1563731 - 1470 WP_000287541.1 beta-Ala-His dipeptidase -
FBF59_RS07950 1563943..1564332 + 390 WP_000712655.1 YxeA family protein -
FBF59_RS07955 1564351..1564527 - 177 WP_000852629.1 stage II sporulation protein SB -
FBF59_RS07960 1564600..1564728 - 129 WP_000237817.1 hypothetical protein Antitoxin
FBF59_RS07965 1564841..1565578 - 738 WP_000624969.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FBF59_RS07970 1565817..1566554 - 738 WP_000594159.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FBF59_RS07975 1566720..1567202 - 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
FBF59_RS07980 1567350..1567478 + 129 WP_003265031.1 hypothetical protein -
FBF59_RS07985 1567454..1568299 + 846 Protein_1567 alpha-keto acid decarboxylase family protein -
FBF59_RS07990 1568453..1569235 - 783 WP_000381785.1 class I SAM-dependent methyltransferase -
FBF59_RS07995 1569580..1569987 - 408 WP_000072495.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(11-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28383.13 Da        Isoelectric Point: 8.2998

>T124228 WP_000624969.1 NZ_CP039721:c1565578-1564841 [Bacillus thuringiensis]
MISNIRIGLFVLAIFFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T124228 NZ_CP039721:c1565578-1564841 [Bacillus thuringiensis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTTTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT124228 WP_000237817.1 NZ_CP039721:c1564728-1564600 [Bacillus thuringiensis]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp

>AT124228 NZ_CP039721:c1564728-1564600 [Bacillus thuringiensis]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References