Detailed information of TA system TA124223

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 47440..47987
• Replicon: plasmid PNCS014853 strain 14[5]12:i:-
• Accession: NZ_CP039714
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014853

Toxin (Protein)

• Gene name: parE
• Uniprot ID: E9LLH3
• Locus tag: E5N94_RS23975
• Protein ID: WP_000969996.1
• Coordinates: 47440..47721 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E5N94_RS23980
• Protein ID: WP_032181987.1
• Coordinates: 47718..47987 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5N94_RS23945	44067..44669	+	603	WP_045133169.1	proQ/FINO family protein	-
E5N94_RS23950	44725..45219	+	495	WP_001350009.1	hypothetical protein	-
E5N94_RS23955	45219..45485	+	267	WP_000627831.1	hypothetical protein	-
E5N94_RS23965	45962..46435	-	474	WP_077128838.1	hypothetical protein	-
E5N94_RS23970	46552..47400	-	849	WP_001057996.1	3'-5' exonuclease	-
E5N94_RS23975	47440..47721	-	282	WP_000969996.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5N94_RS23980	47718..47987	-	270	WP_032181987.1	hypothetical protein	Antitoxin
E5N94_RS24935	48042..48200	-	159	WP_000841008.1	hypothetical protein	-
E5N94_RS23995	48896..49927	-	1032	WP_044706701.1	replication initiation protein	-
E5N94_RS24010	50900..51163	+	264	WP_001324596.1	ash family protein	-
E5N94_RS24015	51132..51368	+	237	WP_000483804.1	conjugal transfer protein TraA	-
E5N94_RS24025	51810..52343	+	534	WP_001306770.1	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..98012	98012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T124223 WP_000969996.1 NZ_CP039714:c47721-47440 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T124223 NZ_CP039714:c47721-47440 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT124223 WP_032181987.1 NZ_CP039714:c47987-47718 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT124223 NZ_CP039714:c47987-47718 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Structures

Toxin

• AlphaFold DB: E9LLH3