Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1840112..1840629 Replicon chromosome
Accession NZ_CP039704
Organism Hankyongella ginsenosidimutans strain W1-2-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E6W36_RS10780 Protein ID WP_281277298.1
Coordinates 1840112..1840408 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E6W36_RS10785 Protein ID WP_222872601.1
Coordinates 1840408..1840629 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6W36_RS20720 (E6W36_10190) 1835174..1835911 - 738 WP_281277297.1 calcium-binding protein -
E6W36_RS10760 (E6W36_10195) 1835869..1836894 - 1026 WP_222872598.1 M10 family metallopeptidase -
E6W36_RS10765 (E6W36_10200) 1837051..1837524 - 474 WP_222872599.1 Hsp20 family protein -
E6W36_RS10770 (E6W36_10205) 1837695..1838165 + 471 WP_222872600.1 DUF1465 family protein -
E6W36_RS10775 (E6W36_10210) 1838258..1840011 - 1754 Protein_2288 DNA mismatch repair endonuclease MutL -
E6W36_RS10780 (E6W36_10215) 1840112..1840408 - 297 WP_281277298.1 PIN domain-containing protein Toxin
E6W36_RS10785 (E6W36_10220) 1840408..1840629 - 222 WP_222872601.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E6W36_RS10790 (E6W36_10225) 1840829..1841876 + 1048 Protein_2291 rod shape-determining protein -
E6W36_RS10795 (E6W36_10230) 1841948..1842898 + 951 WP_222872602.1 rod shape-determining protein MreC -
E6W36_RS10800 (E6W36_10235) 1842935..1843486 + 552 WP_222872603.1 rod shape-determining protein MreD -
E6W36_RS10805 (E6W36_10240) 1843426..1845342 + 1917 WP_222872604.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-87)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10966.55 Da        Isoelectric Point: 9.1936

>T124218 WP_281277298.1 NZ_CP039704:c1840408-1840112 [Hankyongella ginsenosidimutans]
MLRYMLDTDLCIRVLRDRPAPARERFNREARGLCISTVSLHELLYGAERSARPDHYRVEVARFAARLQVLAFDADAAAHA
ADIRATLEKAGRPSAATT

Download         Length: 297 bp

>T124218 NZ_CP039704:c1840408-1840112 [Hankyongella ginsenosidimutans]
ATGCTGCGTTACATGCTGGACACCGACCTATGCATCCGGGTGCTGCGCGACCGGCCGGCCCCGGCGCGCGAAAGGTTCAA
CCGGGAAGCACGGGGTCTGTGCATCTCGACCGTCAGTCTCCATGAACTGCTCTACGGTGCAGAGCGCTCGGCCCGCCCAG
ACCACTACCGTGTCGAAGTCGCGCGCTTTGCCGCGCGTTTGCAAGTGCTCGCTTTCGATGCCGACGCTGCCGCGCATGCG
GCGGACATTCGCGCCACGCTGGAAAAAGCGGGCAGGCCATCGGCAGCTACGACCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8145.29 Da        Isoelectric Point: 6.2389

>AT124218 WP_222872601.1 NZ_CP039704:c1840629-1840408 [Hankyongella ginsenosidimutans]
MTRTTLFQSNRTQAVRLPKAVAFPEGTNEVVILIDGNTRILIPSEALWDDFFAAEGIALGPRQKPATQQRETF

Download         Length: 222 bp

>AT124218 NZ_CP039704:c1840629-1840408 [Hankyongella ginsenosidimutans]
ATGACACGCACGACCCTGTTTCAATCAAACCGGACCCAGGCTGTGCGGCTGCCCAAAGCGGTCGCATTTCCGGAGGGGAC
CAACGAAGTCGTGATTCTGATCGACGGCAACACGCGCATCCTCATCCCGTCGGAAGCCCTCTGGGACGATTTCTTCGCCG
CCGAAGGCATCGCGCTCGGGCCGCGCCAGAAACCGGCGACCCAGCAGCGCGAAACCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References