Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1614182..1614699 Replicon chromosome
Accession NZ_CP039704
Organism Hankyongella ginsenosidimutans strain W1-2-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E6W36_RS09480 Protein ID WP_222872437.1
Coordinates 1614182..1614526 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E6W36_RS09485 Protein ID WP_246047473.1
Coordinates 1614523..1614699 (-) Length 59 a.a.

Genomic Context

E6W36_RS09460E6W36_RS09465E6W36_RS18710E6W36_RS20640E6W36_RS09475E6W36_RS09480E6W36_RS09485E6W36_RS09490E6W36_RS18725E6W36_RS09495E6W36_RS18730E6W36_RS18735E6W36_RS09500E6W36_RS09505E6W36_RS18740
Location: 1609307..1610584 (1278 bp)
Type: Others
Protein ID: WP_222872433.1
Location: 1610482..1611906 (1425 bp)
Type: Others
Protein ID: Protein_2015
Location: 1611916..1612395 (480 bp)
Type: Others
Protein ID: WP_246048302.1
Location: 1612283..1613461 (1179 bp)
Type: Others
Protein ID: WP_222872435.1
Location: 1613600..1614136 (537 bp)
Type: Others
Protein ID: WP_222872436.1
Location: 1614182..1614526 (345 bp)
Type: Toxin
Protein ID: WP_222872437.1
Location: 1614523..1614699 (177 bp)
Type: Antitoxin
Protein ID: WP_246047473.1
Location: 1614772..1615518 (747 bp)
Type: Others
Protein ID: WP_222872439.1
Location: 1615515..1615586 (72 bp)
Type: Others
Protein ID: WP_246048304.1
Location: 1615664..1616389 (726 bp)
Type: Others
Protein ID: Protein_2023
Location: 1616386..1616499 (114 bp)
Type: Others
Protein ID: WP_246047475.1
Location: 1616496..1616687 (192 bp)
Type: Others
Protein ID: WP_246047477.1
Location: 1616672..1617928 (1257 bp)
Type: Others
Protein ID: WP_246047479.1
Location: 1617925..1618530 (606 bp)
Type: Others
Protein ID: WP_222872440.1
Location: 1618545..1619309 (765 bp)
Type: Others
Protein ID: WP_246048305.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
E6W36_RS09460 (E6W36_08950)1609307..1610584+1278WP_222872433.1integrin alpha-
E6W36_RS09465 (E6W36_08955)1610482..1611906+1425Protein_2015cadherin domain-containing protein-
E6W36_RS187101611916..1612395+480WP_246048302.1integrin alpha-
E6W36_RS206401612283..1613461+1179WP_222872435.1hypothetical protein-
E6W36_RS09475 (E6W36_08965)1613600..1614136-537WP_222872436.1histidine phosphatase family protein-
E6W36_RS09480 (E6W36_08970)1614182..1614526-345WP_222872437.1type II toxin-antitoxin system PemK/MazF family toxinToxin
E6W36_RS09485 (E6W36_08975)1614523..1614699-177WP_246047473.1antitoxin MazE family proteinAntitoxin
E6W36_RS09490 (E6W36_08980)1614772..1615518-747WP_222872439.1adenosylcobinamide-GDP ribazoletransferase-
E6W36_RS187251615515..1615586-72WP_246048304.1hypothetical protein-
E6W36_RS09495 (E6W36_08985)1615664..1616389-726Protein_2023nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase-
E6W36_RS187301616386..1616499-114WP_246047475.1nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase-
E6W36_RS187351616496..1616687-192WP_246047477.1hypothetical protein-
E6W36_RS09500 (E6W36_08990)1616672..1617928-1257WP_246047479.1cobyric acid synthase-
E6W36_RS09505 (E6W36_08995)1617925..1618530-606WP_222872440.1cob(I)yrinic acid a,c-diamide adenosyltransferase-
E6W36_RS187401618545..1619309-765WP_246048305.1TonB-dependent receptor-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(1-57)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12435.41 Da        Isoelectric Point: 9.2944

>T124217 WP_222872437.1 NZ_CP039704:c1614526-1614182 [Hankyongella ginsenosidimutans]
MRRGEIRTVAGGKDYAGKPRPAVIVQDDLFDATDSVTLCAFTTDETDAPLFRLPVQPSPGNGLRAPCRLMVDKITTVHKT
KIGPAIGRLEDDDMLRLNRAMLVFLGLAASPRSR

Download         Length: 345 bp

>T124217 NZ_CP039704:c1614526-1614182 [Hankyongella ginsenosidimutans]
ATGAGGCGCGGCGAAATCCGTACGGTTGCAGGCGGCAAGGACTATGCCGGCAAACCGCGCCCGGCGGTGATCGTGCAGGA
TGACCTGTTCGATGCGACCGACTCCGTCACGCTGTGCGCCTTCACCACCGATGAGACCGATGCGCCGCTGTTTCGGCTGC
CCGTGCAGCCCAGTCCCGGCAACGGCCTGCGCGCGCCCTGCCGCCTGATGGTCGACAAGATCACCACGGTTCACAAGACC
AAGATCGGCCCCGCGATCGGCCGACTGGAAGATGACGACATGCTGCGCCTCAACCGGGCGATGCTGGTGTTCCTGGGGCT
CGCCGCCAGCCCACGCAGCCGCTAG

Antitoxin


Download         Length: 59 a.a.        Molecular weight: 6477.20 Da        Isoelectric Point: 11.9559

>AT124217 WP_246047473.1 NZ_CP039704:c1614699-1614523 [Hankyongella ginsenosidimutans]
VRAHRARLRAQGLRPIQIWVPDVRAASFRAEAHRQSQAVASSRQAHDDQSFIDAVSDA

Download         Length: 177 bp

>AT124217 NZ_CP039704:c1614699-1614523 [Hankyongella ginsenosidimutans]
GTGCGCGCGCATCGGGCCCGGCTGCGGGCGCAGGGGCTGCGACCGATCCAGATCTGGGTTCCGGACGTCCGGGCAGCATC
GTTTCGGGCCGAGGCGCATCGTCAGTCGCAGGCAGTGGCGAGCAGCCGGCAGGCGCATGACGACCAAAGCTTCATCGACG
CCGTGTCCGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References