Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1745539..1746058 Replicon chromosome
Accession NZ_CP039700
Organism Vibrio cyclitrophicus strain ECSMB14105

Toxin (Protein)


Gene name relE Uniprot ID A0A0L1L9L7
Locus tag FAZ90_RS07880 Protein ID WP_010429015.1
Coordinates 1745777..1746058 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K5UYY9
Locus tag FAZ90_RS07875 Protein ID WP_004730320.1
Coordinates 1745539..1745787 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ90_RS07835 1740660..1741382 - 723 WP_016788688.1 hypothetical protein -
FAZ90_RS07840 1741516..1742775 - 1260 WP_016788689.1 SIR2 family protein -
FAZ90_RS07845 1742937..1743674 - 738 WP_016788690.1 hypothetical protein -
FAZ90_RS07850 1744267..1744383 - 117 WP_136952232.1 DUF3265 domain-containing protein -
FAZ90_RS07855 1744387..1744812 - 426 WP_016767909.1 hypothetical protein -
FAZ90_RS07860 1744841..1744933 - 93 WP_193838489.1 DUF3265 domain-containing protein -
FAZ90_RS07865 1744956..1745258 - 303 WP_016795728.1 hypothetical protein -
FAZ90_RS07870 1745372..1745464 - 93 WP_010429030.1 DUF3265 domain-containing protein -
FAZ90_RS07875 1745539..1745787 + 249 WP_004730320.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FAZ90_RS07880 1745777..1746058 + 282 WP_010429015.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FAZ90_RS07885 1746373..1747041 - 669 WP_016795729.1 arginine ABC transporter permease ArtM -
FAZ90_RS07890 1747038..1747724 - 687 WP_046208918.1 arginine ABC transporter permease ArtQ -
FAZ90_RS07895 1747726..1748457 - 732 WP_016769264.1 lysine/arginine/ornithine ABC transporter substrate-binding protein -
FAZ90_RS07900 1748564..1749307 - 744 WP_016769263.1 arginine ABC transporter ATP-binding protein ArtP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10917.91 Da        Isoelectric Point: 10.7726

>T124211 WP_010429015.1 NZ_CP039700:1745777-1746058 [Vibrio cyclitrophicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKR

Download         Length: 282 bp

>T124211 NZ_CP039700:1745777-1746058 [Vibrio cyclitrophicus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCAACGCTTCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCGCATGTTCCGGCTTCAAAACTCTCTGGAGCTGACAACATGTATAAGATTA
AGCTGCGCCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9109.39 Da        Isoelectric Point: 3.9610

>AT124211 WP_004730320.1 NZ_CP039700:1745539-1745787 [Vibrio cyclitrophicus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT124211 NZ_CP039700:1745539-1745787 [Vibrio cyclitrophicus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGTGAACCTGTTGCTGTACTGAACCGAAATGAGCCAGCATTTTATTGCGTACCAGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTTACTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L1L9L7

Antitoxin

Source ID Structure
AlphaFold DB A0A0L1LA33

References