Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3615946..3616572 Replicon chromosome
Accession NZ_CP039695
Organism Novosphingobium sp. ABRDHK2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FA702_RS17520 Protein ID WP_136957138.1
Coordinates 3616204..3616572 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FA702_RS17515 Protein ID WP_136957137.1
Coordinates 3615946..3616200 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA702_RS17490 3611020..3611953 - 934 Protein_3458 IS5 family transposase -
FA702_RS17500 3612713..3613579 - 867 WP_136957134.1 glutathione-dependent disulfide-bond oxidoreductase -
FA702_RS17505 3613755..3614423 - 669 WP_136957135.1 HAD-IA family hydrolase -
FA702_RS17510 3614484..3615863 + 1380 WP_136957136.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
FA702_RS17515 3615946..3616200 + 255 WP_136957137.1 ribbon-helix-helix protein, CopG family Antitoxin
FA702_RS17520 3616204..3616572 + 369 WP_136957138.1 type II toxin-antitoxin system VapC family toxin Toxin
FA702_RS17525 3616585..3618408 + 1824 WP_136957139.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
FA702_RS17530 3618522..3620834 + 2313 WP_136957506.1 GGDEF and EAL domain-containing protein -
FA702_RS17535 3620853..3621530 - 678 WP_136957140.1 phosphoribosylformylglycinamidine synthase subunit PurQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3611020..3611706 686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-40)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13823.07 Da        Isoelectric Point: 8.0392

>T124207 WP_136957138.1 NZ_CP039695:3616204-3616572 [Novosphingobium sp. ABRDHK2]
VADPFFDTNILVDWLKDRPQAVAELSRYKRHRISRIVWAEILAGEPLEQRDTMQQIIAPFEVVEIDARIAATAADIRHRS
RMKLLDALILATAQVNGAILVTRNTKDFPANMPGIRVPYTLC

Download         Length: 369 bp

>T124207 NZ_CP039695:3616204-3616572 [Novosphingobium sp. ABRDHK2]
GTGGCCGATCCGTTCTTCGACACCAACATCCTGGTCGATTGGCTGAAGGACCGCCCGCAGGCCGTGGCCGAACTTTCGCG
CTACAAGCGGCACCGGATCAGCCGGATCGTCTGGGCCGAAATTCTCGCCGGCGAACCGCTCGAACAGCGCGATACCATGC
AGCAGATCATCGCGCCGTTCGAAGTGGTGGAGATCGATGCGCGTATCGCCGCGACGGCGGCGGACATCCGCCATCGCAGC
CGCATGAAGTTGCTCGACGCGCTCATCCTTGCGACCGCGCAAGTCAATGGCGCTATTCTCGTGACACGAAATACCAAGGA
TTTTCCGGCCAACATGCCGGGCATCCGTGTTCCTTACACCCTCTGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9613.59 Da        Isoelectric Point: 5.1315

>AT124207 WP_136957137.1 NZ_CP039695:3615946-3616200 [Novosphingobium sp. ABRDHK2]
MTRILADLPDDDIQWLDARAAEEGKSRASVLREAVASFKAQNRASRRSDWIARGAGYWKDRADIGDAVDYQRTIRDDRTP
YDQV

Download         Length: 255 bp

>AT124207 NZ_CP039695:3615946-3616200 [Novosphingobium sp. ABRDHK2]
ATGACTCGCATTCTTGCCGATCTTCCCGATGATGACATCCAGTGGCTCGATGCCCGCGCCGCCGAAGAGGGCAAGTCGCG
CGCGTCGGTGCTGCGCGAGGCGGTGGCGAGCTTCAAGGCGCAGAACCGTGCGTCGCGCCGCAGCGACTGGATCGCGCGGG
GGGCGGGGTACTGGAAGGACCGCGCCGATATCGGCGATGCGGTCGATTACCAGCGGACGATCCGCGACGATCGCACGCCC
TATGATCAAGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References