Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 56687..57408 Replicon chromosome
Accession NZ_CP039692
Organism Agrobacterium larrymoorei strain CFBP5473

Toxin (Protein)


Gene name vapC Uniprot ID A0A2Z2Q4M6
Locus tag CFBP5473_RS14640 Protein ID WP_051441368.1
Coordinates 56687..57157 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4D7DUK8
Locus tag CFBP5473_RS14645 Protein ID WP_027676571.1
Coordinates 57154..57408 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5473_RS14625 51771..52136 - 366 WP_027676574.1 response regulator -
CFBP5473_RS14630 52376..54190 + 1815 WP_027676573.1 PAS domain-containing methyl-accepting chemotaxis protein -
CFBP5473_RS14635 54448..56637 + 2190 WP_027676572.1 EAL domain-containing protein -
CFBP5473_RS14640 56687..57157 - 471 WP_051441368.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBP5473_RS14645 57154..57408 - 255 WP_027676571.1 plasmid stabilization protein Antitoxin
CFBP5473_RS14650 57593..58567 - 975 WP_027676570.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
CFBP5473_RS14655 58594..60747 - 2154 WP_027676569.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
CFBP5473_RS14660 60717..61130 - 414 WP_027676568.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
CFBP5473_RS14665 61140..61364 - 225 WP_027676567.1 glutaredoxin-like protein NrdH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 40431..57408 16977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17112.76 Da        Isoelectric Point: 7.3185

>T124202 WP_051441368.1 NZ_CP039692:c57157-56687 [Agrobacterium larrymoorei]
MILIDTNVISEPLKPAPYAAVLTWLDAQAIETLFISAISIAERRFGIASMPRGKRQMILHGRLEDEVLPIFEKRILPFNV
GTSQFYANLMASGRASGKVIGKADRYTAATAAEHDLAVATRDASPFEAAGLRVINPWATWTFKITGLEFEPHQSVG

Download         Length: 471 bp

>T124202 NZ_CP039692:c57157-56687 [Agrobacterium larrymoorei]
ATGATTCTAATAGACACCAATGTGATATCTGAGCCTTTGAAGCCGGCTCCTTATGCTGCCGTGCTGACTTGGCTGGATGC
ACAGGCCATCGAAACGCTATTCATTTCCGCGATTTCGATTGCCGAACGTCGTTTCGGGATCGCCTCAATGCCGCGGGGGA
AGCGTCAGATGATCCTACACGGTCGCCTTGAAGATGAAGTTCTACCGATTTTTGAGAAGCGCATTCTACCCTTTAACGTC
GGAACCTCCCAATTTTACGCTAATCTGATGGCCAGCGGTCGCGCATCCGGAAAGGTGATTGGCAAGGCTGATAGATACAC
TGCCGCTACGGCTGCGGAACACGATCTCGCGGTCGCAACGCGAGATGCCAGCCCATTTGAAGCAGCCGGATTGAGAGTTA
TCAATCCTTGGGCCACTTGGACTTTTAAAATTACTGGTCTCGAGTTCGAGCCTCATCAAAGCGTGGGTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9284.60 Da        Isoelectric Point: 8.7216

>AT124202 WP_027676571.1 NZ_CP039692:c57408-57154 [Agrobacterium larrymoorei]
MAAVTIRKLSDETHRALRARATYHGRSTEAEIRDILEAAVRPSGRVKLGSLLAAIGHEAKMSKSDVEALQQQRDLTPEVP
MTFE

Download         Length: 255 bp

>AT124202 NZ_CP039692:c57408-57154 [Agrobacterium larrymoorei]
ATGGCTGCAGTGACTATACGAAAGCTATCTGATGAAACTCATCGAGCGTTGCGCGCGCGAGCAACATATCACGGACGTAG
TACCGAGGCCGAAATTCGTGACATTCTCGAAGCCGCTGTCCGTCCATCTGGACGCGTGAAACTCGGGTCGCTTCTCGCGG
CCATCGGCCATGAAGCCAAAATGTCAAAGAGTGATGTCGAGGCGCTGCAACAACAGCGCGACTTGACCCCGGAAGTACCC
ATGACTTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z2Q4M6

Antitoxin

Source ID Structure
AlphaFold DB A0A4D7DUK8

References