Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2341077..2341615 Replicon chromosome
Accession NZ_CP039691
Organism Agrobacterium larrymoorei strain CFBP5473

Toxin (Protein)


Gene name parE Uniprot ID A0A4D7DQ75
Locus tag CFBP5473_RS11385 Protein ID WP_027675635.1
Coordinates 2341322..2341615 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4D7DS04
Locus tag CFBP5473_RS11380 Protein ID WP_027675634.1
Coordinates 2341077..2341325 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5473_RS11340 2336662..2337150 - 489 WP_027675627.1 DUF1579 domain-containing protein -
CFBP5473_RS11345 2337164..2337892 - 729 WP_027675628.1 thioredoxin family protein -
CFBP5473_RS11350 2338013..2338459 + 447 WP_027675629.1 MarR family winged helix-turn-helix transcriptional regulator -
CFBP5473_RS11360 2338602..2339366 - 765 WP_027675630.1 RES family NAD+ phosphorylase -
CFBP5473_RS11365 2339326..2339709 - 384 WP_027675631.1 MbcA/ParS/Xre antitoxin family protein -
CFBP5473_RS11370 2339833..2340258 - 426 WP_027675632.1 organic hydroperoxide resistance protein -
CFBP5473_RS11375 2340453..2340914 + 462 WP_027675633.1 MarR family transcriptional regulator -
CFBP5473_RS11380 2341077..2341325 + 249 WP_027675634.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CFBP5473_RS11385 2341322..2341615 + 294 WP_027675635.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFBP5473_RS11390 2341669..2342007 - 339 WP_051441286.1 NINE protein -
CFBP5473_RS11395 2342139..2342873 - 735 WP_027675637.1 L,D-transpeptidase -
CFBP5473_RS11400 2343074..2343958 - 885 WP_027675638.1 L,D-transpeptidase -
CFBP5473_RS11405 2344072..2345013 - 942 WP_027675639.1 S9 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11088.47 Da        Isoelectric Point: 6.3222

>T124200 WP_027675635.1 NZ_CP039691:2341322-2341615 [Agrobacterium larrymoorei]
MKALALSPAAEADLDHIWEHSATNWGLDQADRYTDEIRDACLDLAAGVRHGRPVDVRSGYLKYNTGAHMIYFRDQGDRLD
IVRILHQRQDVIFNLPK

Download         Length: 294 bp

>T124200 NZ_CP039691:2341322-2341615 [Agrobacterium larrymoorei]
ATGAAGGCCCTTGCTCTCTCGCCTGCGGCAGAAGCGGACCTTGACCACATTTGGGAACACAGCGCCACGAATTGGGGGCT
GGATCAGGCCGACCGCTATACCGATGAAATCCGGGATGCCTGCCTTGATCTGGCCGCTGGCGTCAGGCATGGCCGCCCGG
TCGATGTACGCTCCGGCTATCTGAAATATAACACCGGCGCGCATATGATCTACTTCCGCGATCAAGGTGACAGGCTGGAT
ATCGTTCGCATTTTGCATCAAAGACAGGACGTAATCTTTAACCTGCCCAAGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9218.25 Da        Isoelectric Point: 7.2036

>AT124200 WP_027675634.1 NZ_CP039691:2341077-2341325 [Agrobacterium larrymoorei]
MARNTSITLGDHFASFIRDQVQTGRYGSTSDVVRAGLRLLEEHEAKVKSLQDALIAGEQSGEPRAFDFEAFKTRKRAEYE
GR

Download         Length: 249 bp

>AT124200 NZ_CP039691:2341077-2341325 [Agrobacterium larrymoorei]
ATGGCCCGGAACACCTCTATAACGCTCGGAGATCACTTCGCCAGCTTTATCAGGGACCAGGTGCAGACAGGTCGCTACGG
CTCTACGAGTGACGTTGTCCGAGCAGGACTGCGGCTGCTGGAAGAGCATGAGGCCAAGGTGAAGTCCCTTCAAGACGCCC
TGATCGCCGGGGAGCAGTCAGGGGAGCCACGAGCTTTCGACTTTGAGGCATTCAAGACTCGCAAGCGCGCAGAGTATGAG
GGCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7DQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A4D7DS04

References