124197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2053637..2054268 Replicon chromosome
Accession NZ_CP039691
Organism Agrobacterium larrymoorei strain CFBP5473

Toxin (Protein)


Gene name vapC Uniprot ID A0A4D7DKT4
Locus tag CFBP5473_RS09855 Protein ID WP_027675859.1
Coordinates 2053637..2054035 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4D7DRW1
Locus tag CFBP5473_RS09860 Protein ID WP_027675860.1
Coordinates 2054035..2054268 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5473_RS09840 2050727..2051668 + 942 WP_027675856.1 peptidylprolyl isomerase -
CFBP5473_RS09845 2051774..2052790 + 1017 WP_027675857.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
CFBP5473_RS09850 2052790..2053620 + 831 WP_027675858.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CFBP5473_RS09855 2053637..2054035 - 399 WP_027675859.1 type II toxin-antitoxin system VapC family toxin Toxin
CFBP5473_RS09860 2054035..2054268 - 234 WP_027675860.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CFBP5473_RS09865 2054353..2055012 - 660 WP_084631681.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
CFBP5473_RS09870 2055061..2055732 - 672 WP_027675862.1 guanylate kinase -
CFBP5473_RS09875 2055738..2056625 - 888 WP_027675863.1 YicC family protein -
CFBP5473_RS09880 2056683..2057900 - 1218 WP_027675864.1 endolytic transglycosylase MltG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.17 Da        Isoelectric Point: 6.8525

>T124197 WP_027675859.1 NZ_CP039691:c2054035-2053637 [Agrobacterium larrymoorei]
MLTYMLDTNICIYVMKTYPPELREKFNALAEQLCISSITLGELYYGAEKSARRTDNIHAIDNFVARLEVLPFADKAAAHY
GQIRAELTKAGTPCGVHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

>T124197 NZ_CP039691:c2054035-2053637 [Agrobacterium larrymoorei]
ATGCTGACATATATGCTCGATACGAACATATGTATCTATGTGATGAAAACCTATCCGCCTGAATTACGAGAGAAATTCAA
TGCTCTCGCAGAGCAACTTTGCATATCCAGCATCACGCTTGGCGAGCTTTATTACGGTGCCGAGAAATCTGCGCGTCGCA
CCGACAATATCCATGCCATCGACAATTTCGTTGCCAGGCTCGAGGTGCTGCCATTCGCGGATAAGGCCGCTGCGCATTAT
GGGCAGATCAGAGCGGAGCTGACGAAGGCTGGCACGCCCTGTGGTGTTCATGACATGCAAATCGGTGGACATGCTCGAAG
CGAGGGCTTGATTGTCGTCACCAATAATATGCGCGAGTTCGTGCGGATGCCCGGGTTACGGGTCGAGAACTGGGTCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8712.93 Da        Isoelectric Point: 5.8152

>AT124197 WP_027675860.1 NZ_CP039691:c2054268-2054035 [Agrobacterium larrymoorei]
MATSTVFISNRSQAVRLPKAVAFPEDVHKVDVLKVGLTRIIVPQGSRWDDLFLSGPKATQDFLERREEPALDERESF

Download         Length: 234 bp

>AT124197 NZ_CP039691:c2054268-2054035 [Agrobacterium larrymoorei]
ATGGCGACATCCACAGTTTTCATCAGCAATCGCAGTCAGGCTGTCAGACTGCCCAAGGCCGTCGCATTCCCTGAGGATGT
GCACAAGGTTGATGTGCTGAAAGTAGGTCTGACGCGGATTATCGTGCCGCAAGGAAGCCGCTGGGATGATCTTTTTCTCA
GTGGACCCAAGGCTACACAGGATTTTCTTGAACGGCGTGAGGAACCGGCTTTGGACGAGCGCGAGTCCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7DKT4

Antitoxin

Source ID Structure
AlphaFold DB A0A4D7DRW1

References