Detailed information of TA system TA124193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 326782..327349
• Replicon: chromosome
• Accession: NZ_CP039691
• Organism: Agrobacterium larrymoorei strain CFBP5473

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CFBP5473_RS01500
• Protein ID: WP_084631408.1
• Coordinates: 327188..327349 (-)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A4D7DJW9
• Locus tag: CFBP5473_RS01495
• Protein ID: WP_027673541.1
• Coordinates: 326782..327183 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFBP5473_RS01480	322385..325036	+	2652	WP_027673538.1	DNA translocase FtsK	-
CFBP5473_RS01485	325202..325876	+	675	WP_027673539.1	outer membrane lipoprotein carrier protein LolA	-
CFBP5473_RS01490	325965..326768	+	804	WP_027673540.1	exodeoxyribonuclease III	-
CFBP5473_RS01495	326782..327183	-	402	WP_027673541.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CFBP5473_RS01500	327188..327349	-	162	WP_084631408.1	type II toxin-antitoxin system HicA family toxin	Toxin
CFBP5473_RS01505	327429..327884	-	456	WP_027673543.1	cyclic nucleotide-binding domain-containing protein	-
CFBP5473_RS01510	328027..328710	-	684	WP_027673544.1	response regulator transcription factor	-
CFBP5473_RS01515	328854..329399	+	546	WP_037170647.1	transpeptidase	-
CFBP5473_RS01520	329532..330104	-	573	WP_027673546.1	CarD family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (11-50)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5841.95 Da
• Isoelectric Point: 11.8222

>T124193 WP_084631408.1 NZ_CP039691:c327349-327188 [Agrobacterium larrymoorei]
MKSTDIIAALRKGSHVQFKHASKPGRVTVPHPKRDLPIGTLKSIEKQAGLKLR

Nucleotide

• Length: 162 bp

>T124193 NZ_CP039691:c327349-327188 [Agrobacterium larrymoorei]
ATGAAGAGCACTGATATTATAGCGGCACTTCGCAAGGGCAGTCATGTCCAGTTCAAGCATGCTTCGAAACCCGGACGTGT
CACCGTCCCGCATCCCAAGAGAGACTTGCCCATCGGTACGCTTAAAAGCATAGAGAAGCAGGCCGGGTTGAAACTGAGGT
AG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14301.06 Da
• Isoelectric Point: 4.6630

>AT124193 WP_027673541.1 NZ_CP039691:c327183-326782 [Agrobacterium larrymoorei]
MRNYIGLIHKHADSDYGVSFPDFPGVVTAGTDLDDARLMAEEALSLHVEGLLEDGDAIPEPSSLDDVMKDGENKKAVAIL
VSLKSESKRAVRLNITLPEDVLRDIDAYAQAHGLTRSGFLARAAKHEISSASA

Nucleotide

• Length: 402 bp

>AT124193 NZ_CP039691:c327183-326782 [Agrobacterium larrymoorei]
ATGCGGAATTACATCGGACTGATCCACAAGCACGCTGATAGCGATTACGGAGTATCGTTCCCCGACTTCCCAGGCGTCGT
GACTGCTGGAACGGATTTGGATGACGCACGTCTGATGGCCGAGGAAGCGCTATCCCTTCATGTCGAGGGGCTGCTGGAAG
ATGGCGACGCCATTCCCGAGCCATCGAGTCTGGATGACGTTATGAAAGATGGCGAAAACAAAAAGGCTGTCGCAATCCTC
GTTTCGCTGAAGTCCGAGAGCAAGAGAGCCGTTCGCCTTAACATCACCTTGCCTGAAGACGTTCTGCGGGACATCGATGC
TTACGCACAAGCGCACGGATTGACCCGTTCGGGCTTCCTGGCGCGCGCCGCGAAACACGAAATCTCCTCTGCGAGTGCCT
GA

Structures

Antitoxin

• AlphaFold DB: A0A4D7DJW9