Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 326782..327349 Replicon chromosome
Accession NZ_CP039691
Organism Agrobacterium larrymoorei strain CFBP5473

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CFBP5473_RS01500 Protein ID WP_084631408.1
Coordinates 327188..327349 (-) Length 54 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4D7DJW9
Locus tag CFBP5473_RS01495 Protein ID WP_027673541.1
Coordinates 326782..327183 (-) Length 134 a.a.

Genomic Context

CFBP5473_RS01480CFBP5473_RS01485CFBP5473_RS01490CFBP5473_RS01515CFBP5473_RS01495CFBP5473_RS01500CFBP5473_RS01505CFBP5473_RS01510CFBP5473_RS01520
Location: 322385..325036 (2652 bp)
Type: Others
Protein ID: WP_027673538.1
Location: 325202..325876 (675 bp)
Type: Others
Protein ID: WP_027673539.1
Location: 325965..326768 (804 bp)
Type: Others
Protein ID: WP_027673540.1
Location: 328854..329399 (546 bp)
Type: Others
Protein ID: WP_037170647.1
Location: 326782..327183 (402 bp)
Type: Antitoxin
Protein ID: WP_027673541.1
Location: 327188..327349 (162 bp)
Type: Toxin
Protein ID: WP_084631408.1
Location: 327429..327884 (456 bp)
Type: Others
Protein ID: WP_027673543.1
Location: 328027..328710 (684 bp)
Type: Others
Protein ID: WP_027673544.1
Location: 329532..330104 (573 bp)
Type: Others
Protein ID: WP_027673546.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CFBP5473_RS01480322385..325036+2652WP_027673538.1DNA translocase FtsK-
CFBP5473_RS01485325202..325876+675WP_027673539.1outer membrane lipoprotein carrier protein LolA-
CFBP5473_RS01490325965..326768+804WP_027673540.1exodeoxyribonuclease III-
CFBP5473_RS01495326782..327183-402WP_027673541.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
CFBP5473_RS01500327188..327349-162WP_084631408.1type II toxin-antitoxin system HicA family toxinToxin
CFBP5473_RS01505327429..327884-456WP_027673543.1cyclic nucleotide-binding domain-containing protein-
CFBP5473_RS01510328027..328710-684WP_027673544.1response regulator transcription factor-
CFBP5473_RS01515328854..329399+546WP_037170647.1transpeptidase-
CFBP5473_RS01520329532..330104-573WP_027673546.1CarD family transcriptional regulator-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-50)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 5841.95 Da        Isoelectric Point: 11.8222

>T124193 WP_084631408.1 NZ_CP039691:c327349-327188 [Agrobacterium larrymoorei]
MKSTDIIAALRKGSHVQFKHASKPGRVTVPHPKRDLPIGTLKSIEKQAGLKLR

Download         Length: 162 bp

>T124193 NZ_CP039691:c327349-327188 [Agrobacterium larrymoorei]
ATGAAGAGCACTGATATTATAGCGGCACTTCGCAAGGGCAGTCATGTCCAGTTCAAGCATGCTTCGAAACCCGGACGTGT
CACCGTCCCGCATCCCAAGAGAGACTTGCCCATCGGTACGCTTAAAAGCATAGAGAAGCAGGCCGGGTTGAAACTGAGGT
AG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14301.06 Da        Isoelectric Point: 4.6630

>AT124193 WP_027673541.1 NZ_CP039691:c327183-326782 [Agrobacterium larrymoorei]
MRNYIGLIHKHADSDYGVSFPDFPGVVTAGTDLDDARLMAEEALSLHVEGLLEDGDAIPEPSSLDDVMKDGENKKAVAIL
VSLKSESKRAVRLNITLPEDVLRDIDAYAQAHGLTRSGFLARAAKHEISSASA

Download         Length: 402 bp

>AT124193 NZ_CP039691:c327183-326782 [Agrobacterium larrymoorei]
ATGCGGAATTACATCGGACTGATCCACAAGCACGCTGATAGCGATTACGGAGTATCGTTCCCCGACTTCCCAGGCGTCGT
GACTGCTGGAACGGATTTGGATGACGCACGTCTGATGGCCGAGGAAGCGCTATCCCTTCATGTCGAGGGGCTGCTGGAAG
ATGGCGACGCCATTCCCGAGCCATCGAGTCTGGATGACGTTATGAAAGATGGCGAAAACAAAAAGGCTGTCGCAATCCTC
GTTTCGCTGAAGTCCGAGAGCAAGAGAGCCGTTCGCCTTAACATCACCTTGCCTGAAGACGTTCTGCGGGACATCGATGC
TTACGCACAAGCGCACGGATTGACCCGTTCGGGCTTCCTGGCGCGCGCCGCGAAACACGAAATCTCCTCTGCGAGTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A4D7DJW9

References