Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 6177173..6177701 Replicon chromosome
Accession NZ_CP039690
Organism Phreatobacter stygius strain KCTC 52518

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag E8M01_RS29160 Protein ID WP_136963362.1
Coordinates 6177411..6177701 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag E8M01_RS29155 Protein ID WP_136963361.1
Coordinates 6177173..6177418 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M01_RS29125 6173027..6174544 + 1518 WP_136963358.1 MFS transporter -
E8M01_RS29130 6174665..6174886 + 222 WP_136964886.1 LysR family transcriptional regulator -
E8M01_RS29135 6175158..6175532 - 375 WP_211596673.1 ammonium transporter -
E8M01_RS29140 6175529..6175819 - 291 WP_136963359.1 autorepressor SdpR family transcription factor -
E8M01_RS29145 6176124..6176492 + 369 WP_136963360.1 YciI family protein -
E8M01_RS29150 6176646..6176990 - 345 Protein_5786 HRDC domain-containing protein -
E8M01_RS29155 6177173..6177418 + 246 WP_136963361.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
E8M01_RS29160 6177411..6177701 + 291 WP_136963362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8M01_RS29165 6177745..6179604 - 1860 WP_136963363.1 DNA helicase RecQ -
E8M01_RS29170 6179860..6180102 - 243 WP_136963364.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
E8M01_RS29175 6180280..6180918 - 639 WP_136963365.1 glutathione S-transferase family protein -
E8M01_RS29180 6180906..6181355 - 450 WP_136963366.1 SRPBCC domain-containing protein -
E8M01_RS29185 6181352..6181690 - 339 WP_136963367.1 metalloregulator ArsR/SmtB family transcription factor -
E8M01_RS29190 6181676..6182161 + 486 WP_136963368.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 6165677..6177701 12024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(7-79)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11104.71 Da        Isoelectric Point: 9.4744

>T124192 WP_136963362.1 NZ_CP039690:6177411-6177701 [Phreatobacter stygius]
MAEYRLSPRAQRDLDGIFDYTVKQWGLPQALRYTDLIEAACASLAGAPQQSQDCAAIRPGYRRRNVELHVIYFRQTSYGI
AIIRILHQRMDQARHL

Download         Length: 291 bp

>T124192 NZ_CP039690:6177411-6177701 [Phreatobacter stygius]
ATGGCTGAGTATCGGCTCAGTCCGAGAGCGCAGCGCGATCTTGATGGGATCTTCGATTACACCGTGAAGCAATGGGGCCT
GCCCCAGGCGCTGCGCTATACCGACCTTATCGAAGCAGCCTGCGCCAGTTTGGCGGGGGCGCCCCAGCAATCCCAGGACT
GTGCTGCTATTAGACCAGGCTATCGCCGACGCAATGTCGAGCTGCATGTCATCTATTTTCGGCAGACAAGCTACGGGATC
GCAATCATTCGCATCCTGCATCAGCGCATGGACCAGGCCCGTCACCTTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9287.27 Da        Isoelectric Point: 5.6293

>AT124192 WP_136963361.1 NZ_CP039690:6177173-6177418 [Phreatobacter stygius]
MGTVRKTITLTEQQDAWIASQIAAGHYTNDSEAIRDLIRREQERSFEIETIRQALIEGEHSGEPEQFDFAAFKRRKAAQH
G

Download         Length: 246 bp

>AT124192 NZ_CP039690:6177173-6177418 [Phreatobacter stygius]
ATGGGAACCGTGCGCAAGACCATCACCCTGACCGAGCAGCAGGATGCGTGGATCGCCTCGCAAATCGCTGCCGGCCACTA
CACCAACGATAGCGAGGCGATCCGCGACCTGATCCGGCGTGAGCAGGAACGCAGTTTCGAAATCGAGACAATCCGCCAGG
CTCTCATAGAGGGCGAGCATAGCGGCGAGCCGGAGCAATTCGACTTTGCGGCCTTCAAGCGGCGCAAAGCCGCACAACAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References