Detailed information of TA system TA124192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 6177173..6177701
• Replicon: chromosome
• Accession: NZ_CP039690
• Organism: Phreatobacter stygius strain KCTC 52518

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E8M01_RS29160
• Protein ID: WP_136963362.1
• Coordinates: 6177411..6177701 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E8M01_RS29155
• Protein ID: WP_136963361.1
• Coordinates: 6177173..6177418 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8M01_RS29125	6173027..6174544	+	1518	WP_136963358.1	MFS transporter	-
E8M01_RS29130	6174665..6174886	+	222	WP_136964886.1	LysR family transcriptional regulator	-
E8M01_RS29135	6175158..6175532	-	375	WP_211596673.1	ammonium transporter	-
E8M01_RS29140	6175529..6175819	-	291	WP_136963359.1	autorepressor SdpR family transcription factor	-
E8M01_RS29145	6176124..6176492	+	369	WP_136963360.1	YciI family protein	-
E8M01_RS29150	6176646..6176990	-	345	Protein_5786	HRDC domain-containing protein	-
E8M01_RS29155	6177173..6177418	+	246	WP_136963361.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
E8M01_RS29160	6177411..6177701	+	291	WP_136963362.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E8M01_RS29165	6177745..6179604	-	1860	WP_136963363.1	DNA helicase RecQ	-
E8M01_RS29170	6179860..6180102	-	243	WP_136963364.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
E8M01_RS29175	6180280..6180918	-	639	WP_136963365.1	glutathione S-transferase family protein	-
E8M01_RS29180	6180906..6181355	-	450	WP_136963366.1	SRPBCC domain-containing protein	-
E8M01_RS29185	6181352..6181690	-	339	WP_136963367.1	metalloregulator ArsR/SmtB family transcription factor	-
E8M01_RS29190	6181676..6182161	+	486	WP_136963368.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	6165677..6177701	12024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (7-79)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11104.71 Da
• Isoelectric Point: 9.4744

>T124192 WP_136963362.1 NZ_CP039690:6177411-6177701 [Phreatobacter stygius]
MAEYRLSPRAQRDLDGIFDYTVKQWGLPQALRYTDLIEAACASLAGAPQQSQDCAAIRPGYRRRNVELHVIYFRQTSYGI
AIIRILHQRMDQARHL

Nucleotide

• Length: 291 bp

>T124192 NZ_CP039690:6177411-6177701 [Phreatobacter stygius]
ATGGCTGAGTATCGGCTCAGTCCGAGAGCGCAGCGCGATCTTGATGGGATCTTCGATTACACCGTGAAGCAATGGGGCCT
GCCCCAGGCGCTGCGCTATACCGACCTTATCGAAGCAGCCTGCGCCAGTTTGGCGGGGGCGCCCCAGCAATCCCAGGACT
GTGCTGCTATTAGACCAGGCTATCGCCGACGCAATGTCGAGCTGCATGTCATCTATTTTCGGCAGACAAGCTACGGGATC
GCAATCATTCGCATCCTGCATCAGCGCATGGACCAGGCCCGTCACCTTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9287.27 Da
• Isoelectric Point: 5.6293

>AT124192 WP_136963361.1 NZ_CP039690:6177173-6177418 [Phreatobacter stygius]
MGTVRKTITLTEQQDAWIASQIAAGHYTNDSEAIRDLIRREQERSFEIETIRQALIEGEHSGEPEQFDFAAFKRRKAAQH
G

Nucleotide

• Length: 246 bp

>AT124192 NZ_CP039690:6177173-6177418 [Phreatobacter stygius]
ATGGGAACCGTGCGCAAGACCATCACCCTGACCGAGCAGCAGGATGCGTGGATCGCCTCGCAAATCGCTGCCGGCCACTA
CACCAACGATAGCGAGGCGATCCGCGACCTGATCCGGCGTGAGCAGGAACGCAGTTTCGAAATCGAGACAATCCGCCAGG
CTCTCATAGAGGGCGAGCATAGCGGCGAGCCGGAGCAATTCGACTTTGCGGCCTTCAAGCGGCGCAAAGCCGCACAACAT
GGCTGA